Cartilage Imaging: Techniques and Developments

Oei, Edwin H.G.; Wick, Marius C.; Müller‐Lutz, Anja; Schleich, Christoph; Miese, Falk

doi:10.1055/s-0038-1639471

Cited by 19 publications

(18 citation statements)

References 120 publications

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“…Finally, the outcome measurements of clinical studies, such as joint space narrowing on conventional radiography, may not be sensitive enough. With the ongoing advancements in cartilage imaging [49], advanced techniques such as 7-tesla MRI imaging [49] may provide a more sensitive means to evaluate multiple outcome domains relevant to the clinical and pathophysiological aspects of disease modifying osteoarthritis drug (DMOAD)-mediated disease modification.…”

Section: Discussionmentioning

confidence: 99%

Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review

Timur

Caron

Jeuken

et al. 2020

IJMS

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Knee osteoarthritis (OA) is a condition mainly characterized by cartilage degradation. Currently, no effective treatment exists to slow down the progression of OA-related cartilage damage. Selective COX-2 inhibitors may, next to their pain killing properties, act chondroprotective in vivo. To determine whether the route of administration is important for the efficacy of the chondroprotective properties of selective COX-2 inhibitors, a systematic review was performed according to the PRISMA guidelines. Studies investigating OA-related cartilage damage of selective COX-2 inhibitors in vivo were included. Nine of the fourteen preclinical studies demonstrated chondroprotective effects of selective COX-2 inhibitors using systemic administration. Five clinical studies were included and, although in general non-randomized, failed to demonstrate chondroprotective actions of oral selective COX-2 inhibitors. All of the four preclinical studies using bolus intra-articular injections demonstrated chondroprotective actions, while one of the three preclinical studies using a slow release system demonstrated chondroprotective actions. Despite the limited evidence in clinical studies that have used the oral administration route, there seems to be a preclinical basis for considering selective COX-2 inhibitors as disease modifying osteoarthritis drugs when used intra-articularly. Intra-articularly injected selective COX-2 inhibitors may hold the potential to provide chondroprotective effects in vivo in clinical studies.

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Section: Discussionmentioning

confidence: 99%

Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review

Timur

Caron

Jeuken

et al. 2020

IJMS

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“…Building on the preliminary findings, our study provides substantial evidence that compositional changes of the lumbar spine are associated with numerous structural and inflammatory changes in a larger and homogenous cohort of patients with r-axSpA, which is considered the prototypical axSpA disease. GAG depletion is an established sign of early cartilage changes that precedes morphologically visible damage [32,33]. Interestingly, since the 1950s, research has indicated that cartilage loss plays a significant role in the pathophysiology of r-axSpA, too [34,35].…”

Section: Discussionmentioning

confidence: 99%

Functional MR imaging beyond structure and inflammation—radiographic axial spondyloarthritis is associated with proteoglycan depletion of the lumbar spine

et al. 2020

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Background To compare the glycosaminoglycan (GAG) content of lumbar intervertebral disks (IVDs) of patients with ankylosing spondylitis (AS) and healthy volunteers and to investigate the association of GAG depletion and disease-related clinical and imaging features. Methods Lumbar spines of 50 AS patients (mean age 50 ± 10.5 years) and 30 age-matched volunteers were studied with 3-T magnetic resonance imaging (MRI) and conventional radiographs (CR). The MRI protocol included high-resolution morphological sequences and the compositional GAG chemical exchange saturation transfer imaging technique (gagCEST). Morphological images were analyzed by three raters for inflammatory activity, fat deposition, disk degeneration, and structural changes on CR. Clinical and serological measures included the Bath AS Disease Activity (BASDAI) and Bath AS Function (BASFI) Indices and C-reactive protein (CRP) levels. GagCEST values of both groups were compared using a linear mixed model. Kendall-Tau correlation analyses were performed. Results GagCEST values were significantly lower in AS patients (2.0 ± 1.7%) vs. healthy volunteers (2.4 ± 1.8%), p = 0.001. Small, yet significant correlations were found between gagCEST values and CRP levels (τ = − 0.14, p = 0.007), BASFI (τ = − 0.18, p < 0.001) and presence of syndesmophytes (τ = − 0.17, p = 0.001). No significant correlations were found with BASDAI, inflammation, and fat deposition MRI scores. Conclusions Lumbar spines of r-AS patients undergo significant GAG depletion, independently associated with syndesmophyte formation, functional disability, and increased serological inflammation markers. Beyond establishing a pathophysiological role of the cartilage in AS, these findings suggest that gagCEST imaging may have an adjunct confirmatory role in the assessment of disease-related pathological MRI findings in axial spondyloarthritis. Trial registration 3980 (https://studienregister.med.uni-duesseldorf.de)

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“…The most superficial layer, the lamina splendens, is composed of horizontally oriented parallel collagen fibers, resulting in relative hypointensity on images. 26,27 MR Imaging Evaluation of Pathology…”

Section: Mr Imaging Appearance Of Normal Articular Cartilagementioning

confidence: 99%

“…Joint irritation may provoke a reactive synovitis, often containing chondral debris and/or frank loose bodies. 26,27 Numerous grading systems have been devised for semiquantitative analysis of the degree and extent of chondral damage on MR imaging. Some, such as the modified Outerbridge and modified Noyes scores, focus solely on changes involving the articular cartilage.…”

Section: Evaluation Of Chondral Damagementioning

confidence: 99%

Advanced Magnetic Resonance Imaging in Osteoarthritis

Burge

Jawetz

2020

Semin Musculoskelet Radiol

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Osteoarthritis (OA) is one of the most common causes of disability throughout the world. Current therapeutic strategies are aimed at preventing the development and delaying the progression of OA, as well as repairing or replacing worn articular surfaces, because the regeneration of lost hyaline articular cartilage is not currently a clinically feasible option. Imaging is useful in formulating treatment strategies in patients at risk for OA, allowing assessment of risk factors, the degree of preexisting tissue damage, and posttreatment monitoring. Magnetic resonance imaging (MRI), in particular, provides in-depth evaluation of these patients, with optimal clinical sequencing allowing sensitive assessment of chondral signal and morphology, and the addition of advanced MRI techniques facilitating comprehensive evaluation of joint health, with increased sensitivity for changes in articular cartilage and surrounding joint tissues.

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Cartilage Imaging: Techniques and Developments

Cited by 19 publications

References 120 publications

Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review

Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review

Functional MR imaging beyond structure and inflammation—radiographic axial spondyloarthritis is associated with proteoglycan depletion of the lumbar spine

Advanced Magnetic Resonance Imaging in Osteoarthritis

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