Cartilage regeneration in osteoarthritic knees treated with distal femoral osteotomy and intra-lesional implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells: A report of two cases

Song, Jun-Seob; Hong, Ki-Taek; Kim, Na-Min; Jung, Jae-Yub; Park, Han-Soo; Chun, You Seung; Kim, Seok Jung

doi:10.1016/j.knee.2019.07.017

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…20 More recently, the mixture of hUCB-MSCs with HA has been used to repair large cartilage defects of the knee under arthrotomy. [8][9][10][11][12][13]21 Arthroscopy allows better visualization due to magnification, provides easier access to the cartilage defect approaching from several different angles, and leads to earlier gain of the range of motion and less scar formation compared with arthrotomy. However, arthroscopic hUCB-MSCs implantation is not easy because the collapse of anterior soft tissue might make the working space smaller and remnant saline solution might dilute hUCB-MSCs.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, open arthrotomy using a 3-5-cm incision often has been used for hUCB-MSCs implantation. [8][9][10][11][12][13]21 To achieve successful dry arthroscopy and safe implantation, several techniques have been applied to Before dry arthroscopy, retraction needle positioning and far medial working portal creation should be completed in conventional arthroscopy with saline solution. The holes should be created as close as possible for better coverage of the cartilage defect, but drilling should be performed carefully to avoid connecting neighboring holes, which might cause subchondral fracture.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dry arthroscopy with a simple retraction technique for knee joint cartilage repair using allogenic human umbilical cord blood-derived mesenchymal stem cells

Oh¹,

Kwon²

2021

Arthroscopy Techniques

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dry arthroscopy with a simple retraction technique for knee joint cartilage repair using allogenic human umbilical cord blood-derived mesenchymal stem cells

Oh¹,

Kwon²

2021

Arthroscopy Techniques

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“…In the complex management of OA, physical exercise turned out to be effective also in synergy with other innovative therapies (i.e., mesenchymal cell implants or injections). In this scenario, autologous chondrocyte implants and bone marrow-derived mesenchymal cell implants or injections are innovative therapeutic interventions in OA focused on articular cartilage and subchondral bone damage treatment [ 93 , 94 , 95 ]. Studies in humans showed that exercise might enhance joint recruitment of bone marrow-derived mesenchymal stem cells and upregulates the expression of osteogenic and chondrogenic genes (Runx, MSx1, Sox9, COL2A1, ATG3), osteogenic microRNAs, and osteogenic growth factors (BMP2, BMP6) [ 87 , 96 , 97 ].…”

Section: Physical Exercise As a Modulator Of Osteoarthritis Molecular Pathwaysmentioning

confidence: 99%

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Sire

Marotta

Marinaro

et al. 2021

IJMS

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Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the catabolism of the cartilage extracellular matrix and is supported by inflammatory and oxidative signaling pathways and marked epigenetic changes. To delay OA progression, a wide range of exercise programs and naturally derived compounds have been suggested. This literature review aims to analyze the main signaling pathways and the evidence about the synergistic effects of these two interventions to counter OA. The converging nutrigenomic and physiogenomic intervention could slow down and reduce the complex pathological features of OA. This review provides a comprehensive picture of a possible signaling approach for targeting OA molecular pathways, initiation, and progression.

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“…There is increasing interest in treating articular cartilage and subchondral bone defects and osteoarthritis with autologous chondrocyte implants (ACIs), matrix autologous chondrocyte implants (MACIs), and bone marrow-derived mesenchymal cell implants or injections [8][9][10][11][12][13][14]. ACI and MACI procedures have been shown to produce durable long-term outcomes in the treatment of partial and full-thickness articular cartilage defects in tibiofemoral joints [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Exercise as an Adjuvant to Cartilage Regeneration Therapy

Smith

2020

IJMS

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This article provides a brief review of the pathophysiology of osteoarthritis and the ontogeny of chondrocytes and details how physical exercise improves the health of osteoarthritic joints and enhances the potential of autologous chondrocyte implants, matrix-induced autologous chondrocyte implants, and mesenchymal stem cell implants for the successful treatment of damaged articular cartilage and subchondral bone. In response to exercise, articular chondrocytes increase their production of glycosaminoglycans, bone morphogenic proteins, and anti-inflammatory cytokines and decrease their production of proinflammatory cytokines and matrix-degrading metalloproteinases. These changes are associated with improvements in cartilage organization and reductions in cartilage degeneration. Studies in humans indicate that exercise enhances joint recruitment of bone marrow-derived mesenchymal stem cells and upregulates their expression of osteogenic and chondrogenic genes, osteogenic microRNAs, and osteogenic growth factors. Rodent experiments demonstrate that exercise enhances the osteogenic potential of bone marrow-derived mesenchymal stem cells while diminishing their adipogenic potential, and that exercise done after stem cell implantation may benefit stem cell transplant viability. Physical exercise also exerts a beneficial effect on the skeletal system by decreasing immune cell production of osteoclastogenic cytokines interleukin-1β, tumor necrosis factor-α, and interferon-γ, while increasing their production of antiosteoclastogenic cytokines interleukin-10 and transforming growth factor-β. In conclusion, physical exercise done both by bone marrow-derived mesenchymal stem cell donors and recipients and by autologous chondrocyte donor recipients may improve the outcome of osteochondral regeneration therapy and improve skeletal health by downregulating osteoclastogenic cytokine production and upregulating antiosteoclastogenic cytokine production by circulating immune cells.

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Cartilage regeneration in osteoarthritic knees treated with distal femoral osteotomy and intra-lesional implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells: A report of two cases

Cited by 16 publications

References 11 publications

Dry arthroscopy with a simple retraction technique for knee joint cartilage repair using allogenic human umbilical cord blood-derived mesenchymal stem cells

Dry arthroscopy with a simple retraction technique for knee joint cartilage repair using allogenic human umbilical cord blood-derived mesenchymal stem cells

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Exercise as an Adjuvant to Cartilage Regeneration Therapy

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