“…A previous systematic review revealed that the application of manga positively influenced health care settings (Branscum & Sharma, 2009 ). Several randomized controlled trials reported a small effect on initiatives of health behavior change for promoting general health (Junhasavasdikul et al, 2017 ) and for preventing back pain (Kovacs et al, 2011 ). However, other studies challenged the application of health promotion manga or comics for a range of patient education or health education initiatives, such as programs for promoting physical activity and healthy diet (Baranowski et al, 2002 ; Branscum, Sharma, Wang, Wilson, & Rojas-Guyler, 2013a , 2013b ; Leung et al, 2017 ; Leung, Tripicchio, Agaronov, & Hou, 2014 ; Manes, Liu, Burke, & Dworkin, 2014 ); the prevention infectious diseases (Bieri, Yuan et al, 2013 ; Yuan, Manderson, Tempongko, Wei, & Aiguo, 2000 ), HIV/AIDS (Dworkin et al, 2013 ; Gillmore et al, 1997 ), and cancer (Lyzun & McMullen, 2009 ; Risi et al, 2004 ); immunization (Diamond et al, 2016 ; Muzumdar & Nania, 2015 ; Muzumdar & Pantaleo, 2017 ); smoking cessation (Bush et al, 2005 ); reduction of disease-related stigma (el-Setouhy & Rio, 2003 ), education on pesticide exposure and health (Liebman, Juárez, Leyva, & Corona, 2007 ); prevention of accidents among children (Cardenas & Simons-Morton, 1993 ); and patient education (Maxwell, Simmons, Franklin, Arnold, & Pall, 2014 ; Shigehatake et al, 2014 ).…”