Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression

Hotta, Mariko; Nakata, Rieko; Katsukawa, Michiko; Hori, Kazuyuki; Takahashi, Saori; Inoue, H.

doi:10.1194/jlr.m900255-jlr200

Cited by 226 publications

(204 citation statements)

References 39 publications

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“…46,47) Similarly, essential oil components such as carvacrol and citral activate PPARs and suppress COX-2 expression. [48][49][50] These findings suggest that various food-derived components, including resveratrol, have similar effects on PPARs and COX-2.…”

Section: Introductionmentioning

confidence: 63%

Recent Advances in the Study on Resveratrol

Nakata

Takahashi

Inoue

2012

Biological & Pharmaceutical Bulletin

Self Cite

152

112

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Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.

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Section: Introductionmentioning

confidence: 63%

Recent Advances in the Study on Resveratrol

Nakata

Takahashi

Inoue

2012

Biological & Pharmaceutical Bulletin

Self Cite

152

112

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“…28) Also, previous research has indicated that carvacrol in thyme oils suppresses the LPS-induced expression of cyclooxygenase-2 (COX-2) mRNA and protein, which can cause repression of inflammation. 34) Thus, the T. vulgaris essential oil (which consists of 2.03% carvacrol) exhibited a significant anti-inflammatory activity in this study. This is the first study to analyze the chemical compositions of the essential oils of L. anagallis and P. fragrans (Table 4).…”

Section: Resultsmentioning

confidence: 85%

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Tsai

Lin

et al. 2011

Bioscience, Biotechnology, and Biochemistry

155

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“…The symbols are as in Fig. 3, (Amyloid stain) an important role in inflammation (Hotta et al 2010). For this reason, antioxidants as CAR are potentially useful in positively influencing the systemic redox balance and in consequence tissue inflammation and MDA (Fabian et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

et al. 2015

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Acute pancreatitis (AP) is considered as major problem around the world and the incidence of AP is increasing. Carvacrol (CAR), a monoterpenic phenol, has good antioxidant activity. This in vivo study was designed to evaluate whether CAR provide protection against AP that developed by pancreas injury. The rats were randomised into groups to receive (I) no therapy; (II) 50 lg/kg cerulein at 1 h intervals by four intraperitonally (i.p.) injections; (III) 50, 100 and 200 mg/kg CAR by one i.p. injection; and (IV) cerulein plus CAR after 2 h of cerulein administration. 12 h later, serum samples were obtained to assess pancreatic function, the lipase and amylase values. The oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as malondialdehyde (MDA) and changes in main tissue antioxidant enzyme levels including SOD, CAT and GSH-PX. Histopathological examination was performed using scoring systems. Additionally, oxidative DNA damage was determined by measuring the increases of 8-hydroxy-deoxyguanosine (8-OH-dG) formations. We found that the increasing doses of CAR decreased AP-induced MDA and 8-OH-dG levels. Moreover, the pancreas antioxidant enzyme activities were higher than that of the rats in the AP group when compared to the AP plus CAR group. In the treatment groups, the lipase and amylase were reduced. Besides, histopathological findings in the pancreatic tissue were alleviated (p \ 0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to pancreas.

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Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression

Cited by 226 publications

References 39 publications

Recent Advances in the Study on Resveratrol

Recent Advances in the Study on Resveratrol

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

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