Carvacrol ameliorates haematological parameters, oxidant/antioxidant biomarkers and pulmonary function tests in patients with sulphur mustard‐induced lung disorders: A randomized double‐blind clinical trial

Khazdair, Mohammad Reza; Alavinezhad, Azam; Boskabady, Mohammad Hossein

doi:10.1111/jcpt.12684

Cited by 39 publications

(34 citation statements)

References 38 publications

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“…in other experimental models for carvacrol. In fact, the anti‐inflammatory potential of carvacrol has been evaluated in two recent clinical trials, indicating that its clinical use is effective for the management of inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

“…From these mechanisms, carvacrol and thymol are able to attenuate the leucocyte migration characteristic of the first phase of tissue repair, as demonstrated by Riella et al [12] and Karami et al [20] for thymol, and by Pina et al [44] and Guimarães et al [40] in other experimental models for carvacrol. In fact, the anti-inflammatory potential of carvacrol has been evaluated in two recent clinical trials, [45,46] indicating that its clinical use is effective for the management of inflammatory conditions. Subsequently, the proliferative phase begins, which is divided into four stages: re-epithelialization, angiogenesis, formation of granulation tissue and deposition of collagen.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2019

Journal of Pharmacy and Pharmacology

107

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Objectives The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Methods This review was performed at PubMed, SCOPUS, Web of Science databases using keywords as wound healing, thymol/carvacrol and essential oils. Thirteen studies were selected for discussion. Key findings Thymol/carvacrol was able to act in the three phases of wound healing. In the first phase, they showed modulatory effect of the inflammatory cytokines, oxidative stress and antimicrobial power. In the second phase, they promoted re‐epithelialization, angiogenesis and development of granulation tissue. Finally, in the third phase, they improve the collagen deposition and modulated the growth of fibroblasts and keratinocytes. Conclusions These compounds present a high potential for the development of new therapeutic for wound repair. However, dose, efficacy and safety of these compounds for the treatment of wounds, as well as the mechanisms by which those effects can be observed, are challenges for future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2019

Journal of Pharmacy and Pharmacology

107

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“…Another randomized clinical trial demonstrated that carvacrol (a monoterpenic phenol and principle compound of volatile oil in different plants species) at a dose of 1.2 mg/kg per day decreases blood cells counts including neutrophil after 1 and 2 months of treatment compared with the placebo group (Khazdair, Alavinezhad, & Boskabady, ).…”

Section: Neutrophil‐targeted Drug Delivery In Respiratory Diseasesmentioning

confidence: 99%

Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases

Chellappan

Yee

Xuan

et al. 2020

Drug Development Research

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Neutrophils are essential effector cells of immune system for clearing the extracellular pathogens during inflammation and immune reactions. Neutrophils play a major role in chronic respiratory diseases. In respiratory diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, lung cancer and others, there occurs extreme infiltration and activation of neutrophils followed by a cascade of events like oxidative stress and dysregulated cellular proteins that eventually result in apoptosis and tissue damage. Dysregulation of neutrophil effector functions including delayed neutropil apoptosis, increased neutrophil extracellular traps in the pathogenesis of asthma, and chronic obstructive pulmonary disease enable neutrophils as a potential therapeutic target. Accounting to their role in pathogenesis, neutrophils present as an excellent therapeutic target for the treatment of chronic respiratory diseases. This review highlights the current status and the emerging trends in novel drug delivery systems such as nanoparticles, liposomes, microspheres, and other newer nanosystems that can target neutrophils and their molecular pathways, in the airways against infections, inflammation, and cancer. These drug delivery systems are promising in providing sustained drug delivery, reduced therapeutic dose, improved patient compliance, and reduced drug toxicity. In addition, the review also discusses emerging strategies and the future perspectives in neutrophil-based therapy. K E Y W O R D S nanoparticle, neutrophils, novel drug delivery, pulmonary, respiratory diseases

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“…There were eight studies that used the following doses for oral administration: three animal studies used 73 mg/kg (one dose) (Şen et al, 2014); 80 mg kg −1 day −1 (for 7 days) (Ozer et al, 2017); and 25 and 50 mg/kg (for 7 days) ( Barnwal et al, 2018); four studies with humans used a dose of 1.2 mg kg −1 day −1 (all four studies offered carvacrol for 2 months) (Alavinezhad, 2018;Khazdair et al, 2018;Khazdair & Boskabady, 2019a;Khazdair & Boskabady, 2019b); and one study used a dose of 1 or 2 mg kg −1 day −1 (for 1 month) (Ghorani et al, 2019). In administration via nebulization, the concentration was 240 μl in 5 ml of saline solution (one dose) (de Carvalho et al, 2019).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…orally. All of the human studies that analyzed chronic lung injury (Khazdair et al, 2018;Khazdair & Boskabady, 2019a, 2019b) used a dose of 1.2 mg kg −1 day −1 of encapsulated carvacrol.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Anti‐inflammatory and antioxidant activity of carvacrol in the respiratory system: A systematic review and meta‐analysis

Carvalho

Silva

Gomes

et al. 2020

Phytotherapy Research

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Carvacrol is a monoterpene present in the essential oil of a number of plants and has been widely used in traditional medicine because it is considered to have a range of therapeutic effects including in relation to respiratory disease. To conduct a systematic review and meta‐analysis to assess the anti‐inflammatory and antioxidant activities of carvacrol when used in the treatment of respiratory disorders. A comprehensive literature search using Scopus, MEDLINE‐PubMed, Cochrane and Web of Science was undertaken. Papers related to the anti‐inflammatory or antioxidant properties of carvacrol in the treatment of an injury in the respiratory system in in vivo studies and published in the period up to and including August 2019. A total of 152 studies were initially identified, with only 17 meeting the inclusion criteria. Five of the studies were performed in humans, and 12 were performed in rodents. Among the 17 studies included in the systematic review, we performed the meta‐analysis with nine of the studies with animals. Carvacrol had a positive effect on the reduction of interleukin (IL)‐1β, IL‐4, IL‐8 and malondialdehyde (MDA); however, the analysis indicated that carvacrol had no effect on IL‐6 and tumor necrosis factor alpha (TNF‐α), probably due to the methodological quality of the studies and their heterogeneity. Current evidence supports the antioxidant and anti‐inflammatory effects of carvacrol, but its relationship with the reduction of some inflammatory mediators in animals with lung injury needs further elucidation.

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Carvacrol ameliorates haematological parameters, oxidant/antioxidant biomarkers and pulmonary function tests in patients with sulphur mustard‐induced lung disorders: A randomized double‐blind clinical trial

Abstract: Two-month treatment with CAR reduced inflammatory cells and oxidant biomarkers, whereas increased antioxidant biomarkers and improved PFT tests in SM-exposed patients.

Cited by 39 publications

References 38 publications

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases

Anti‐inflammatory and antioxidant activity of carvacrol in the respiratory system: A systematic review and meta‐analysis

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