Carvacrol inhibits the excessive immune response induced by influenza virus A via suppressing viral replication and TLR/RLR pattern recognition

Zheng, Kui; Wu, Sizhi; Lv, Yiwen; Peng, Ping; Deng, Li; Xu, Huachong; Shi, Yucong

doi:10.1016/j.jep.2020.113555

Cited by 25 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…on Influenza A virus reported that carvacrol reduced lung tissue damage and the proportions of Treg, Th17, Th2 and Th1 in CD4 + T cells as well as inhibited the expression of inflammation-associated cytokines (Zheng et al, 2021). It was also reported that oregano oil and its principal component, carvacrol changed the content of viral membrane cholesterol and blocked the entry of HIV-1 into the host cell (Mediouni et al, 2020).…”

Section: Discussionmentioning

confidence: 97%

“…For enteric viruses, Sánchez et al (2015) indicated that 0.5% of carvacrol completely inactivates the two norovirus surrogates, while one log reduction in Hepatitis A virus and four log reduction in infectiousness of Feline calicivirus. A study evaluating the impacts of carvacrol on Influenza A virus reported that carvacrol reduced lung tissue damage and the proportions of Treg, Th17, Th2 and Th1 in CD4 + T cells as well as inhibited the expression of inflammation‐associated cytokines (Zheng et al, 2021). It was also reported that oregano oil and its principal component, carvacrol changed the content of viral membrane cholesterol and blocked the entry of HIV‐1 into the host cell (Mediouni et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro antiviral activity of Thymbra spicata L. extract on bovine respiratory viruses (BCoV, BPIV-3, BRSV, BVDV and BoHV-1)

Toker

Yeşilbağ

2022

Journal of Applied Microbiology

View full text Add to dashboard Cite

Aims: Viral pathogens are the primary agents in bovine respiratory disease cases, and there is no direct effective antiviral drug application. Thymbra is a genus of oregano commonly found in Turkey. The primary component (34.9%) of the extract obtained from Thymbra spicata L. is the carvacrol which is used in traditional medicine. This study evaluates the potential antiviral activity and inactivation efficiency of T. spicata L. extract against bovine respiratory viruses, including BCoV, BPIV-3, BRSV, BVDV and BoHV-1. Methods and Results:To evaluate its effect on viral replication, viral titres were taken from infected cells treated with non-cytotoxic T. spicata L. extract concentrations (0.75% and 1.5%, 1.32 and 2.64 µg/ml of carvacrol as active ingredient, respectively) and compared to non-treated infected cells. The viruses were treated directly with 1.5% T. spicata L. extract, and the viral titres were evaluated at certain time points to determine the efficiency of direct inactivation. The number of infectious virions for BCoV, BPIV-3, BRSV, BVDV and BoHV-1 treated with 1.5% T. spicata L. extract were decreased by 99.44%, 100.0%, 94.38%, 99.97% and 99.87%, respectively.T. spicata L. extract strongly inhibits the replication of mentioned viruses in a dosedependent manner in vitro. In addition, T. spicata L. extract shared direct inactivation efficiency on the mentioned viruses in a time-dependent manner. Conclusion: This study shows the antiviral efficiency of T. spicata L. on BRD-related viral agents for the first time. The oregano species T. spicata and its main component, carvacrol, may have a potential for antiviral activity in the alternative treatment of respiratory viral diseases in cattle. Significance and Impact of the Study: Given the similarity of replication strategies, obtained data suggest the possible efficiency of T. spicata L. on human respiratory viruses.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

In vitro antiviral activity of Thymbra spicata L. extract on bovine respiratory viruses (BCoV, BPIV-3, BRSV, BVDV and BoHV-1)

Toker

Yeşilbağ

2022

Journal of Applied Microbiology

View full text Add to dashboard Cite

show abstract

“…Consequently, polyphenolic compounds (flavonoids, phenolic acid, and so on) have been suggested as health boosters due to their capacity to donate hydrogens or electrons to free radicals, thus stabilizing them [ 117 ]. The key component of OEOs, including carvacrol, demonstrated the ability to reduce lung tissue damage (edema, hyperemia, and lymphocyte infiltration) caused by influenza virus A, which has been identified because of an overreaction of the innate immune system [ 118 ].…”

Section: Research Innovation and Technological Perspectivesmentioning

confidence: 99%

Mexican Oregano (Lippia graveolens Kunth) as Source of Bioactive Compounds: A Review

et al. 2021

View full text Add to dashboard Cite

Lippia graveolens is a traditional crop and a rich source of bioactive compounds with various properties (e.g., antioxidant, anti-inflammatory, antifungal, UV defense, anti-glycemic, and cytotoxicity) that is primarily cultivated for essential oil recovery. The isolated bioactive compounds could be useful as additives in the functional food, nutraceuticals, cosmetics, and pharmaceutical industries. Carvacrol, thymol, β-caryophyllene, and p-cymene are terpene compounds contained in oregano essential oil (OEO); flavonoids such as quercetin O-hexoside, pinocembrin, and galangin are flavonoids found in oregano extracts. Furthermore, thermoresistant compounds that remain in the plant matrix following a thermal process can be priced in terms of the circular economy. By using better and more selective extraction conditions, the bioactive compounds present in Mexican oregano can be studied as potential inhibitors of COVID-19. Also, research on extraction technologies should continue to ensure a higher quality of bioactive compounds while preventing an undesired chemical shift (e.g., hydrolysis). The oregano fractions can be used in the food, health, and agricultural industries.

show abstract

“…Emerging infectious diseases are produced by organisms with the capability of transferring from person to person, being a serious threat to human health ( Sehgal et al, 2020 ). Recently scientists investigated the effects of natural products on emerging infectious diseases, including the influenza virus, DENV, Zika, and EBOV ( Zheng et al, 2021 ). Considering the common dysregulated pathophysiological mechanisms of emerging infectious diseases and the capability of some phytochemicals in passing BBB ( Fakhri et al, 2020b ) urge the need to introduce candidate phytochemicals as potential modulators of peripheral complications, extrapolated to the same dysregulations in CNS.…”

Section: Phytochemicals Against Emerging Infectious Diseases: Mechanistic Approaches To Neurological Signsmentioning

confidence: 99%

Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals

et al. 2021

View full text Add to dashboard Cite

Growing studies are revealing the critical manifestations of influenza, dengue virus (DENV) infection, Zika virus (ZIKV) disease, and Ebola virus disease (EVD) as emerging infectious diseases. However, their corresponding mechanisms of major complications headed for neuronal dysfunction are not entirely understood. From the mechanistic point of view, inflammatory/oxidative mediators are activated during emerging infectious diseases towards less cell migration, neurogenesis impairment, and neuronal death. Accordingly, the virus life cycle and associated enzymes, as well as host receptors, cytokine storm, and multiple signaling mediators, are the leading players of emerging infectious diseases. Consequently, chemokines, interleukins, interferons, carbohydrate molecules, toll-like receptors (TLRs), and tyrosine kinases are leading orchestrates of peripheral and central complications which are in near interconnections. Some of the resulting neuronal manifestations have attracted much attention, including inflammatory polyneuropathy, encephalopathy, meningitis, myelitis, stroke, Guillain-Barré syndrome (GBS), radiculomyelitis, meningoencephalitis, memory loss, headaches, cranial nerve abnormalities, tremor, and seizure. The complex pathophysiological mechanism behind the aforementioned complications urges the need for finding multi-target agents with higher efficacy and lower side effects. In recent decades, the natural kingdom has been highlighted as promising neuroprotective natural products in modulating several dysregulated signaling pathways/mediators. The present study provides neuronal manifestations of some emerging infectious diseases and underlying pathophysiological mechanisms. Besides, a mechanistic-based strategy is developed to introduce candidate natural products as promising multi-target agents in combating major dysregulated pathways towards neuroprotection in influenza, DENV infection, ZIKV disease, and EVD.

show abstract

Carvacrol inhibits the excessive immune response induced by influenza virus A via suppressing viral replication and TLR/RLR pattern recognition

Cited by 25 publications

References 38 publications

In vitro antiviral activity of Thymbra spicata L. extract on bovine respiratory viruses (BCoV, BPIV-3, BRSV, BVDV and BoHV-1)

In vitro antiviral activity of Thymbra spicata L. extract on bovine respiratory viruses (BCoV, BPIV-3, BRSV, BVDV and BoHV-1)

Mexican Oregano (Lippia graveolens Kunth) as Source of Bioactive Compounds: A Review

Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals

Contact Info

Product

Resources

About