2019
DOI: 10.3390/ijms20205202
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Carvedilol Ameliorates Experimental Atherosclerosis by Regulating Cholesterol Efflux and Exosome Functions

Abstract: Carvedilol (Cav), a nonselective β-blocker with α1 adrenoceptor blocking effect, has been used as a standard therapy for coronary artery disease. This study investigated the effects of Cav on exosome expression and function, ATP-binding cassette transporter A1 (ABCA1) expression, and cholesterol efflux that are relevant to the process of atherosclerosis. Human monocytic (THP-1) cell line and human hepatic (Huh-7) cells were treated with Cav, and cholesterol efflux was measured. Exosomes from cell culture mediu… Show more

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Cited by 20 publications
(18 citation statements)
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“…Macrophage cholesterol efflux and reverse cholesterol transport (RCT) substantially protect against the progression of atherosclerosis [12,13]. ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) mediate cholesterol efflux from foam cells to the extracellular cholesterol acceptors apolipoprotein A-I (ApoA-I) and high-density lipoprotein (HDL), respectively, thereby limiting foam cell formation and decreasing the progression of atherosclerosis [14,15].…”
Section: Introductionmentioning
confidence: 99%
“…Macrophage cholesterol efflux and reverse cholesterol transport (RCT) substantially protect against the progression of atherosclerosis [12,13]. ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) mediate cholesterol efflux from foam cells to the extracellular cholesterol acceptors apolipoprotein A-I (ApoA-I) and high-density lipoprotein (HDL), respectively, thereby limiting foam cell formation and decreasing the progression of atherosclerosis [14,15].…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, in cardiomyocytederived exosomes after treatment with simvastatin, decorin is increased, and periostin is decreased (human exosomes, in vitro) (109). Additionally, carvedilol increases ABCA1 levels in serum exosomes interfering with NF-κB and Akt signaling to limit atherosclerosis (mouse exosomes in a mouse model) (110).…”
Section: Potential Therapeutic Methods Target Exosome Synthesis Proce...mentioning
confidence: 99%
“…β-Blockers β-blockers have an essential role in the management of the atherosclerotic disease (77,78) by inhibiting the sympathetic system, exhibiting antioxidant and anti-inflammation effects (79). Their roles have also been extended to the KD coronary disease.…”
Section: Angiotensin II Receptor Blocker Angiotensin Converting Enzyme Inhibitormentioning
confidence: 99%