Carvone Hypoglycemic and Hypolipidemic effects by regulation of key proteins involved in fatty acid beta-oxidation in alloxan-induced diabetic rats.

Abstract

Essential oils are natural products with various biological characteristics caused by monoterpenes which have a high probability of producing new drugs. Carvone, monoterpenes have hypolipidemic, antiinflammatory, hypoglycemic and antioxidant effects. Aim: The aim of this research is to show that carvone has medicinal potential in the treatment of diabetes and hyperlipidemia in alloxan-induced diabetic rats, as well as its effect on insulin activity. Material and methods: Four groups of male albino rats were formed, each with eight rats. In Group 1, healthy rats were provided a standard chow diet and were not given any medications. To develop diabetes, the rats in the other three groups were given a single intraperitoneal administration of alloxan (120 mg/kg), followed by a two-week feeding of an atherogenic hypercholesterolemic diet. The diabetic hyperlipidemic control (DHC) group received no treatment, while the other two groups received carvone (50 mg/kg) daily for one month and a combination drug (atorvastatin 10 mg/kg and metformin100 mg/kg) daily for one month, respectively. Results: our findings show a reduction in the levels of blood glucose, cholesterol, triglyceride, LDL, fatty acid desaturase -1(FADS-1), glucose-6-phosphate catalase -1(G6PC-1). In contrast, There was an increase in the level of insulin and Acyle-co-A oxidase-1(ACOX-1) upon administration of carvone. Immunohistochemical investigation and other results agree with biochemical indicators to a great extent. Conclusion: Carvone has anti-diabetic and anti-hyperlipidemia properties in diabetic hyperlipidemic rats by controlling essential proteins involved in fatty acid beta-oxidation