Essential oils are natural products with various biological characteristics caused by monoterpenes which have a high probability of producing new drugs. Carvone, monoterpenes have hypolipidemic, antiinflammatory, hypoglycemic and antioxidant effects. Aim: The aim of this research is to show that carvone has medicinal potential in the treatment of diabetes and hyperlipidemia in alloxan-induced diabetic rats, as well as its effect on insulin activity. Material and methods: Four groups of male albino rats were formed, each with eight rats. In Group 1, healthy rats were provided a standard chow diet and were not given any medications. To develop diabetes, the rats in the other three groups were given a single intraperitoneal administration of alloxan (120 mg/kg), followed by a two-week feeding of an atherogenic hypercholesterolemic diet. The diabetic hyperlipidemic control (DHC) group received no treatment, while the other two groups received carvone (50 mg/kg) daily for one month and a combination drug (atorvastatin 10 mg/kg and metformin100 mg/kg) daily for one month, respectively. Results: our findings show a reduction in the levels of blood glucose, cholesterol, triglyceride, LDL, fatty acid desaturase -1(FADS-1), glucose-6-phosphate catalase -1(G6PC-1). In contrast, There was an increase in the level of insulin and Acyle-co-A oxidase-1(ACOX-1) upon administration of carvone. Immunohistochemical investigation and other results agree with biochemical indicators to a great extent. Conclusion: Carvone has anti-diabetic and anti-hyperlipidemia properties in diabetic hyperlipidemic rats by controlling essential proteins involved in fatty acid beta-oxidation

Background: We recently adapted the published Royal College of Pediatrics and Child Health (RCPCH) clinical practice guideline (CPG) for the management of children with an altered level of consciousness (ALOC) to the Alexandria University Children's Hospital (AUCH) context. It is hypothesized that adapting clinical practice guidelines (CPGs) to the local healthcare situation, rather than developing them, will increase their acceptance without putting a large strain on the resources. Aim: To present the adaptation pathway that was used to create the first local CPG in AUCH for the management of children with ALOC. Methods: For CPG adaption, we utilized the 'Adapted ADAPTE' approach. We went over the entire process in depth, including the setup, adaptation, and finalization phases. Results: Eight major recommendations were adopted by the panel from one source (RCPCH) guideline. The recommendations included: (i) service organization and training, (ii) recognition of the health problem and referral, (iii) diagnostic approach (iv) providing support (v) management of ALOC, and (vi) indication to PICU admission (vii) recommended medications (viii)monitoring and follow up. Conclusions: The finalized CPG provides evidence-based guidelines to healthcare providers for the management of children with ALOC in AUCH. The initiative also established the efficacy of the 'Adapted ADAPTE,' as well as the importance of clinical and methodology expert panel collaboration for local CPG adaptation.

No abstract

In this paper, can introduce transform equations that change integral equations into differential equations that are translated on the fuzzy form (FH). using fuzzy Riemann (FR), fuzzy Aumann (FA), and fuzzy Henstock. The algorithm that could solve a Volterra-type integral equation (VIE) was applied to the earlier forms which call triangular fuzzy function to find the fuzzy solution. We present solution as fuzzy functions such that each function satisfies the initial value problem by some membership degree. Some specific examples were provided to fulfil the effectiveness approach.