Cascade-activatable NO release based on GSH-detonated “nanobomb” for multi-pathways cancer therapy

Feng, Yi; Zhang, Hanxi; Xie, Xiaoxue; Chen, Yu; Yang, Geng; Wei, Xiaodan; Li, Ningxi; Li, Mengyue; Li, Tingting; Qin, Xiang; Li, Shun; You, Fengming; Wu, Chunhui; Yang, Hong; Liu, Yiyao

doi:10.1016/j.mtbio.2022.100288

Cited by 20 publications

(18 citation statements)

References 52 publications

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“…Mechanisms Designs PDT Photosensitizers produce ROS under light irradiation Relieve tumor hypoxia [87,88] Increase tumor uptake [79] Combine immunotherapy [89,90] SDT Sonosensitizer produce ROS under ultrasonic irradiation Increase the degree of inertial cavitation [80] Increased targeting [91][92][93][94] Disrupting the redox balance in the cell [95] CDT Fenton reaction produce ROS Metal based nanomaterials [81] CT Anthracyclines induce CRT exposure and ROS production: DOX, Oxp, mitoxantrone, and so on Responsive nanoplatforms as drug carriers [82,84,[96][97][98][99] PTT Photothermal effect Photothermal nanomaterials [83,[100][101][102] Other regulation modes Gas therapy: hydrogen (H 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H 2 S), sulfur dioxide (SO 2 ), and so on induce ERS Gas nanogenerator [103][104][105][106][107] Calcium ion regulation Calcium ions overload [85] cells including myeloid-derived suppressor cells (MDSCs) and regulatory cells (Tregs), whereas it increased cytotoxic T lymphocytes to enhance ICD.…”

Section: Treatment Modesmentioning

confidence: 99%

“…[133] In addition to this, gas therapy was also demonstrated to initiate ICD directly. [103][104][105][106] For example, Wang et al constructed a polynitrosated polyesters-based NO nanogenerator (NanoNO) and demonstrated that NO had the ability to trigger ICD. [107] In this system, NanoNO could control NO release by intracellular glutathione (GSH).…”

Section: Other Regulation Modesmentioning

confidence: 99%

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Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Meng

Ding

et al. 2023

Small Methods

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Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) and immunogenic cell death (ICD), as important cell death mechanisms, are widely reported in cancer therapy, and understanding the relationship between the two is significant for clinical tumor treatments. Considering that vast nanodrugs are developed to induce tumor PCD and ICD simultaneously, in this review, the interrelationship between PCD and ICD is described using nanomedicines as examples. First, an overview of PCD patterns and focus on the morphological differences and interconnections among them are provided. Then the interrelationship between apoptosis and ICD in terms of endoplasmic reticulum stress is described by introducing various cancer treatments and the recent developments of nanomedicines with inducible immunogenicity. Next, the crosstalk between non‐apoptotic (including necrosis, ferroptosis, pyroptosis, and autophagy) signaling pathways and ICD is introduced and their relationship through various nanomedicines as examples is further illustrated. Finally, the relationship between PCD and ICD and its application prospects in the development of new ICD nanomaterials are summarized. This review is believed to deepen the understanding of the relationship between PCD and ICD, extend the biomedical applications of various nanodrugs, and promote the progress of clinical tumor therapy.

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Section: Treatment Modesmentioning

confidence: 99%

Section: Other Regulation Modesmentioning

confidence: 99%

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Meng

Ding

et al. 2023

Small Methods

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“…[117] To overcome the poor biodegradability of MSN, responsive biodegradation of mesoporous silica can be achieved based on stimuli such as temperature, pH, and redox. [118][119][120][121] In addition, the biodegradation of mesoporous silica can be promoted by adjusting the structure of mesoporous silica nano-framework such as introducing organic molecules to achieve organic-inorganic hybridization [122] or doping with metal materials. [123] A recent study exploited the supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and 𝛽-cyclodextrin-modified poly(2methacryloyloxyethylphosphorylcholine) (CD-PMPC) to construct a light-responsive bifunctional biodegradable MSNs.…”

Section: Synthesis Of Degradable Msnsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles‐Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in Anticancer Therapeutics

Feng

Liao

et al. 2023

Adv Healthcare Materials

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In recent years, researchers are developing novel nanoparticles for diagnostic applications using imaging techniques and for therapeutic purposes through drug delivery techniques. The unique physical and chemical properties of mesoporous silica nanoparticles (MSNs) make it possible to integrate a variety of commonly used therapeutic and imaging agents to construct a multimodal synergistic anticancer drug delivery system. Herein, recent advances in MSNs synthesis for drug delivery and smart response applications are reviewed. First, synthetic strategies for the fabrication of ordered MSNs, hollow MSNs, core-shell structured MSNs, dendritic MSNs, and biodegradable MSNs are outlined. Then, the recent research progress in designing functional MSN materials with various controlled release mechanisms in anticancer therapy is discussed, and new properties are introduced to suggest the latest design requirements as drug delivery materials. The review also highlights significant achievements in bioimaging using MSNs and their multifunctional counterparts as delivery vehicles. Finally, personal views on key directions for future work in this area are presented.

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“…11−13 Among them, NO was the first found gaseous biochemical messenger, and it played a dual role in tumor progression: low concentrations of NO might promote tumor growth, while high concentrations of NO (>1 μM) could induce tumor cell apoptosis through multiple pathways. 14 In addition, when NO was used in combination with other therapeutic methods (chemotherapy, 15−17 photothermal therapy, 18,19 radiotherapy, 20 gene therapy, 21 etc. ), a synergistic antitumor effect was anticipated.…”

Section: Introductionmentioning

confidence: 99%

“…To effectively treat cancer, researchers have tried a variety of treatments including gene therapy, − chemotherapy, , radiotherapy, , and gas therapy. − As an emerging treatment, gas therapy uses gas transmitters to induce tumor cell death. Studies have found that several gas molecules, such as nitric oxide (NO), carbon monoxide (CO), oxygen (O 2 ), and hydrogen sulfide (H 2 S), could regulate the process of cancer. − Among them, NO was the first found gaseous biochemical messenger, and it played a dual role in tumor progression: low concentrations of NO might promote tumor growth, while high concentrations of NO (>1 μM) could induce tumor cell apoptosis through multiple pathways . In addition, when NO was used in combination with other therapeutic methods (chemotherapy, − photothermal therapy, , radiotherapy, gene therapy, etc.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

Yang

Guo

et al. 2023

Mol. Pharmaceutics

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The combination cancer therapy of nitric oxide (NO) with gene therapy is a promising method for tumor treatment. However, efficient co-delivery of gas and therapeutic genes to tumor cells remains a challenge. Herein, we designed a nano-sized ultraviolet (UV) light-responsive cationic lipid vector DPNO(Zn). Fluorescence spectroscopy and confocal imaging experiments revealed that DPNO(Zn) lipid nanoparticles (LNPs) could rapidly release NO under low-power UV light irradiation. Moreover, the fluorescence turn-on might take place along with the release of NO, indicating the self-reporting ability. Gene delivery experiments showed that DPNO(Zn) LNPs had good gene transfection ability, making such materials a good candidate for gas/gene combination therapy. In vitro antitumor assay demonstrated that the co-delivery system was more effective in inhibiting tumor cell proliferation than individual NO or pTrail treatment. Studies on the mechanism of tumor cell apoptosis induced by NO/pTrail co-delivery showed that NO could not only effectively increase the accumulation of p53 protein in tumor cells, thereby promoting the activation of caspase-3, but also induce mitochondrial damage. On the other hand, the Trail protein expressed by pTrail gene could enhance the degree of NO-induced caspase-3 activation, indicating the synergistic effect. These results proved that DPNO(Zn) LNP may serve as a multifunctional nanocarrier for potential tumor therapy.

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Cascade-activatable NO release based on GSH-detonated “nanobomb” for multi-pathways cancer therapy

Cited by 20 publications

References 52 publications

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Mesoporous Silica Nanoparticles‐Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in Anticancer Therapeutics

Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

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