2015
DOI: 10.1016/j.cmi.2015.02.007
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Case–control comparison of bacterial and protozoan microorganisms associated with gastroenteritis: application of molecular detection

Abstract: The introduction of molecular detection of infectious organisms has led to increased numbers of positive findings, as observed for pathogens causing gastroenteritis (GE). However, because little is known about the prevalence of these pathogens in the healthy asymptomatic population, the clinical value of these additional findings is unclear. A case-control study was carried out in a population of patients served by general practitioners in the Netherlands. A total of 2710 fecal samples from case and matched co… Show more

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Cited by 62 publications
(71 citation statements)
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“…However, the authors of the other study argued that DEC was one of important enteric pathogen causing acute diarrhea [33]. The detection rate of DEC in present study was lower than that presented in other study [32], but it was higher than that presented in other region of China [11].…”
Section: Discussioncontrasting
confidence: 77%
“…However, the authors of the other study argued that DEC was one of important enteric pathogen causing acute diarrhea [33]. The detection rate of DEC in present study was lower than that presented in other study [32], but it was higher than that presented in other region of China [11].…”
Section: Discussioncontrasting
confidence: 77%
“…In a study from the Netherlands (Holland) by de Wit et al (144), D. fragilis was detected more frequently in the stool specimens of healthy controls (14.6%) than in the stool specimens of subjects suffering from GI complaints (10.3%). A recent large case-controlled comparison study comprising 1,515 symptomatic patients and 1,195 healthy controls detected D. fragilis in 390 symptomatic patients at a prevalence of 25.7% and in 446 individuals in the control group at a prevalence of 37.3% (145). This study found that D. fragilis was more commonly found in healthy nonsymptomatic groups than in symptomatic patients.…”
Section: Clinical Aspects and Epidemiologymentioning
confidence: 50%
“…While there is certainly overwhelming circumstantial evidence incriminating D. fragilis as a pathogen, this is based primarily on case reports or prospective and retrospective studies describing symptomatic patients whose symptoms were resolved following therapeutic intervention and parasite eradication. Other studies have highlighted higher rates of carriage of D. fragilis in control groups or cohorts of patients who are asymptomatic (145). These conflicting data have led to uncertainty about the role that this parasite plays in GI disease.…”
Section: Pathogenicitymentioning
confidence: 97%
“…This calls into question the clinical significance of molecular detection of these pathogens. For D. fragilis, the rate of colonisation was higher in children and parents without AGE, supporting the ongoing debate about its pathogenicity [23].…”
Section: Discussionmentioning
confidence: 89%