Case of Malarial Hepatitis by<i>Plasmodium Vivax</i>

Sung, Young Ho; Park, Joon Mo

doi:10.4166/kjg.2010.56.5.329

Cited by 4 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of jaundice and liver dysfunction in P. falciparum malaria varied from 5.3% to 62% and from 2.5% to 21%, respectively, in different reports,82–84 while malarial hepatitis is rare in P. vivax infection 85. Case-fatality rate in malaria-related hepatic failure is elevated, up to 40%84–86 when high parasite density is associated with jaundice and liver dysfunction 87.…”

Section: Specific Complications Of Severe Malaria Infectionmentioning

confidence: 99%

Pathogenesis of Malaria in Tissues and Blood

Autino¹,

Corbett²,

Castelli

et al. 2012

Mediterr J Hematol Infect Dis

100

View full text Add to dashboard Cite

The clinical manifestations of severe malaria are several and occur in different anatomical sites. Both parasite- and host-related factors contribute to the pathogenicity of the severe forms of the disease. Cytoadherence of infected red blood cells to the vascular endothelium of different organs and rosetting are unique features of malaria parasites which are likely to contribute to the vascular damage and the consequent excessive inflammatory/immune response of the host. In addition to cerebral malaria or severe anaemia, which are quite common manifestation of severe malaria, clinical evidences of thrombocytopenia, acute respiratory distress syndrome (ARDS), liver and kidney disease, are reported. In primigravidae from endemic areas, life threatening placental malaria may also be present.In the following pages, some of the pathogenetic aspects will be briefly reviewed and then data on selected and less frequent manifestation of severe malaria, such as liver or renal failure or ARDS will be discussed.

show abstract

Section: Specific Complications Of Severe Malaria Infectionmentioning

confidence: 99%

Pathogenesis of Malaria in Tissues and Blood

Autino¹,

Corbett²,

Castelli

et al. 2012

Mediterr J Hematol Infect Dis

100

View full text Add to dashboard Cite

show abstract

“…Pitfalls in the diagnosis of imported malaria could occur due to delayed symptoms, especially among those who return after long stays in endemic countries as observed in the 2 nd and 3 rd cases; this could either be due to weaning of immunity following absence of repeated exposure to malaria after return [14,15], or suppression of a partially resistant strain of P. falciparum to repeated doses of amodiaquine given as prophylaxis or as part of treatment in an endemic setting [16]. Altered symptomatology, occurrence of more severe forms of illness due to vivax malaria, liver and renal involvement, and reduction in platelet counts [17-19] may lead to erroneous diagnoses such as dengue fever or leptospirosis, as observed in the 4 th and 5 th cases. Waning of skills and experience of microscopists (2 nd and 3 th cases) due to the low incidence of malaria may also contribute to a delay in diagnosis [20].…”

Section: Discussionmentioning

confidence: 99%

What clinicians who practice in countries reaching malaria elimination should be aware of: lessons learnt from recent experience in Sri Lanka

Premaratna

Galappaththy

Chandrasena

et al. 2011

Malar J

View full text Add to dashboard Cite

Following progressive reduction in confirmed cases of malaria from 2002 to 2007 (41,411 cases in 2002, 10,510 cases in 2003, 3,720 cases in 2004, 1,640 cases in 2005, 591 cases in 2006, and 198 cases in 2007). Sri Lanka entered the pre-elimination stage of malaria in 2008. One case of indigenous malaria and four other cases of imported malaria are highlighted here, as the only patients who presented to the Professorial Medical Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka over the past eight years, in contrast to treating several patients a week about a decade ago. Therefore, at the eve of elimination of malaria from Sri Lanka, it is likely that the infection is mostly encountered among travellers who return from endemic areas, or among the military who serve in un-cleared areas of Northern Sri Lanka. They may act as potential sources of introducing malaria as until malaria eradication is carried out. These cases highlight that change in the symptomatology, forgetfulness regarding malaria as a cause of acute febrile illness and deterioration of the competency of microscopists as a consequence of the low disease incidence, which are all likely to contribute to the delay in the diagnosis. The importance regarding awareness of new malaria treatment regimens, treatment under direct observation, prompt notification of suspected or diagnosed cases of malaria and avoiding blind use of anti-malarials are among the other responsibilities expected of all clinicians who manage patients in countries reaching malaria elimination.

show abstract

“…10 The incidence of jaundice and liver dysfunction in Plasmodium falciparum malaria varies from 5.3% to 62% and from 2.5% to 21%, respectively, in different reports, while malarial hepatitis is rare in Plasmodium vivax infection. [11][12][13][14] Case-fatality rate in malaria-related hepatic failure is elevated to 40% when high parasite density is associated with jaundice and liver dysfunction. 15,16 The objective of our study was to evaluate changes in biochemical parameters in malaria patients and to correlate them with parasite density calculated using the gold standard (thick smear microscopy).…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional observational study assessing the liver function in malarial patients

2021

View full text Add to dashboard Cite

Background: Malaria is a major cause of morbidity in the tropics, being a disease of global importance that results in 300-500 million cases annually. Liver involvement manifests as jaundice, hyperbilirubinemia, hepatomegaly and elevated enzymes (transaminases and alkaline phosphatase). Our objective in this study was to evaluate the role of liver function as an indicator of malaria in endemic regions and as a marker of disease severity.Methods: This was an observational cross-sectional study conducted in central laboratory, department of pathology, central laboratory, department of biochemistry, and out-patient department, department of medicine, medical college Baroda and SSG hospital over a period of ten months, from February, 2019 to November, 2019 and included 137 microscopy proven malaria positive cases. The parasite density on peripheral smear was graded as scanty, moderate and heavy. After procuring the records of serum bilirubin, SGPT and SGOT, statistical analysis of the data was performed.Results: All the 3 parameters show maximum derangement in severe parasitemia with mean values of 3.57, 81.44, and 92.9. While comparing vivax and falciparum malaria, all the LFTs studied show greater derangement in Plasmodium Falciparum when compared to Plasmodium vivax, with greatest difference seen in bilirubin levels (27.78% cases with hyperbilirubinemia in Plasmodium vivax versus 71.43% cases of Plasmodium falciparum showing hyperbilirubinemia).Conclusions: We conclude that altered liver function in form of hyperbilirubinemia and increased liver enzymes in a patient with acute febrile illness increase the probability of malaria, hence directing the clinician along the correct path of further work-up and accurate treatment.

show abstract

Case of Malarial Hepatitis byPlasmodium Vivax

Cited by 4 publications

References 8 publications

Pathogenesis of Malaria in Tissues and Blood

Pathogenesis of Malaria in Tissues and Blood

What clinicians who practice in countries reaching malaria elimination should be aware of: lessons learnt from recent experience in Sri Lanka

A cross-sectional observational study assessing the liver function in malarial patients

Contact Info

Product

Resources

About