Case Report and Review of Primary Bone Diffuse Large B-Cell Lymphoma Involving the Calcaneus

Blume, Peter; Charlot-Hicks, Farlyn; Mohammed, Samirah

doi:10.1053/j.jfas.2013.03.013

Cited by 9 publications

(29 citation statements)

References 35 publications

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“…Common treatment for isolated primary bone lymphomas is chemotherapy alone or in combination with radiotherapy (2-4). However, there are rare reports of surgical excision before chemotherapy (11). We treated this patient through the protocol of our center for primary bone lymphomas, which is a combination of chemotherapy and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Primary Lymphoma of the Calcaneus: A Case Report

Jamshidi

Ahangar

2016

Shafa Ortho J

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Introduction: Primary Non-Hodgkin's lymphoma (NHL) of the bone is a rare condition. Calcaneus is also an uncommon site for this kind of lymphoma. Case Presentation: We hereby present a case of primary non-Hodgkin's lymphoma of the calcaneus, which was diagnosed and treated at our hospital. The patient had a minor twisting trauma of his ankle but symptoms were present for one year after trauma. The patient complained from instability and swelling of his ankle. After paraclinic assessments, a pathologic lesion was detected in his calcaneus, so incisional biopsy was done and the pathology diagnosis was a large B-cell non-Hodgkin's lymphoma. Bone marrow assessment was negative for the disease. The patient was treated by chemotherapy and radiotherapy and currently the disease is in remission and patient is doing his previous full activity without any important complication. Conclusions: Lymphoma is a rare condition in the foot region but we suggest to be more wise for chronic, uncommon symptoms after minor injuries, as lymphoma of the bone can present mysterious and nonspecific symptoms as was seen in this patient. It may be better to do more assessments to prevent delayed diagnosis of such rare conditions. These rare cases may have atypical imaging and clinical appearance, which can lead to misdiagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Rare cases of calcaneal lymphoma have been reported in the literature (11). Here we present a case of primary non-Hodgkin's lymphoma of the calcaneus, which was diagnosed and treated at our hospital.…”

Section: Introductionmentioning

confidence: 88%

Primary Lymphoma of the Calcaneus: A Case Report

Jamshidi

Ahangar

2016

Shafa Ortho J

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“…The symptoms vary from mild non-specific pain to soft tissue swelling, often with a lack of constitutional symptoms ( 96 – 98 ). A number of cases may be accompanied by a pathological fracture ( 95 , 96 , 98 ). A physical examination of the affected hind foot may reveal non-pitting oedema, reddening and tenderness ( 97 , 99 ).…”

Section: Malignant Calcaneal Tumour Typesmentioning

confidence: 99%

“…Radiographs reveal a mixture of osteolysis and sclerotic lesions of the calcaneus, which produce a ‘moth-eaten’ and patchy appearance ( 96 – 98 , 101 ). Periosteal reaction, pathologic fracture and soft tissue involvement may additionally be observed ( 99 , 100 ).…”

Section: Malignant Calcaneal Tumour Typesmentioning

confidence: 99%

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Primary tumours of the calcaneus (Review)

et al. 2018

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The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system. The majority of patients with benign tumours heal, except for a few with a palindromia. For malignant tumours, the prognosis is comparatively poor, resulting in disability and a high rate of metastasis. This review describes the spectrum of calcaneal tumour types and specifically illustrates the epidemiology, symptomatology, imagology, histopathology and treatment options that may facilitate diagnosis and improve prognosis.

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Diagnoses, treatment, and oncologic outcomes in patients with calcaneal malignances: Case series, systematic literature review, and pooled cohort analysis

Newman

Rein

Theyskens

et al. 2020

Journal of Surgical Oncology

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Background and Objectives: Malignant tumors of the calcaneus are rare but pose a treatment challenge. Aims: (1) describe the demographics of calcaneal malignancies in a large cohort; (2) describe survival after amputation versus limb-salvage surgery for high-grade tumors. Methods: Study group: a "pooled" cohort of patients with primary calcaneal malignancies treated at two cancer centers (1984−2015) and systematic literature review. Kaplan−Meier analyses described survival across treatment and diagnostic groups; proportional hazards modeling assessed mortality after amputation versus limb salvage. Results: A total of 131 patients (11 treated at our centers and 120 patients from 53 published studies) with a median 36-month follow-up were included. Diagnoses included Ewing sarcoma (41%), osteosarcoma (30%), and chondrosarcoma (17%); 5-year survival rates were 43%, 73% (70%, high grade only), and 84% (60%, high grade only), respectively. Treatment involved amputation in 52%, limb salvage in 27%, and no surgery in 21%. There was no difference in mortality following limb salvage surgery (vs. amputation) for high-grade tumors (HR 0.38; 95% CI 0.14−1.05), after adjusting for Ewing sarcoma diagnosis (HR 5.15; 95% CI 1.55−17.14), metastatic disease at diagnosis (HR 3.88; 95% CI 1.29−11.64), and age (per-year HR 1.04; 95% CI 1.02−1.07). Conclusions: Limb salvage is oncologically-feasible for calcaneal malignancies.

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Case Report and Review of Primary Bone Diffuse Large B-Cell Lymphoma Involving the Calcaneus

Cited by 9 publications

References 35 publications

Primary Lymphoma of the Calcaneus: A Case Report

Primary Lymphoma of the Calcaneus: A Case Report

Primary tumours of the calcaneus (Review)

Diagnoses, treatment, and oncologic outcomes in patients with calcaneal malignances: Case series, systematic literature review, and pooled cohort analysis

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