Case report: Backward gait training combined with gait-synchronized cerebellar transcranial alternating current stimulation in progressive supranuclear palsy

Shima, Atsushi; Tanaka, Kazuki; Ogawa, Akari; Omae, Erika; Miyake, Tomoaki; Nagamori, Yui; Miyata, Yusuke; Ohata, K.; Ono, Yumie; Mima, Tatsuya; Takahashi, Ryosuke; Koganemaru, Satoko

doi:10.3389/fnhum.2023.1082555

Cited by 3 publications

(6 citation statements)

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“…Changes in clinical balance were observed in 6 rehabilitation studies (30,32,33,35,36,40). These studies had a sample size ranging from 1 (40) to 24 (30). The number of sessions ranged from 10 (40) to 24 sessions (33).…”

Section: Effect Of Rehabilitation Interventions On Clinical Balance I...mentioning

confidence: 99%

“…The number of sessions ranged from 10 (40) to 24 sessions (33). Most studies used the Berg Balance Scale (BBS) to assess clinical balance, while one study used the Mini-BESTest (40). Different interventions were used such as treadmill training (30), body-weight supported treadmill gait training (33), balance and resistance training (35), cueing balance-exercises (36), and backward gait training combined with gait-synchronized transcranial alternating current stimulation (tACS) (40).…”

Section: Effect Of Rehabilitation Interventions On Clinical Balance I...mentioning

confidence: 99%

“…Using a different intervention approach, Shima et al (40) assessed the effect of 10 sessions of rehabilitation (backward gait training) combined with gait-synchronized, cerebellar transcranial alternating current stimulation (tACS) on the MiniBESTest score in a 70-yearold woman with PSP-Richardson's syndrome. Initially, the participant underwent short-term intervention with combined training of backward gait with synchronized cerebellar tACS, asynchronized, or sham stimulation according to the N-of-1 study design.…”

Section: Frontiersinorgmentioning

confidence: 99%

“…Although clinical balance was assessed in 6 rehabilitation studies (30,(33)(34)(35)(36)40), 3 of these studies used a quasi-experimental design (33,35,36), 2 used a case report (34,40,(44)(45)(46)(47), and only one study used an experimental design (30). Thus, the effects of balance-and gait-focused rehabilitation for people with PSP are still unknown due to small sample sizes.…”

Section: Frontiersinorgmentioning

confidence: 99%

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Balance and gait in progressive supranuclear palsy: a narrative review of objective metrics and exercise interventions

et al. 2023

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BackgroundThe use of objective gait and balance metrics is rapidly expanding for evaluation of atypical parkinsonism, and these measures add to clinical observations. Evidence for rehabilitation interventions to improve objective measures of balance and gait in atypical parkinsonism is needed.AimOur aim is to review, with a narrative approach, current evidence on objective metrics for gait and balance and exercise interventions in progressive supranuclear palsy (PSP).MethodsLiterature searches were conducted in four computerized databases from the earliest record up to April 2023: PubMed, ISI’s Web of Knowledge, Cochrane’s Library, and Embase. Data were extracted for study type (cross-sectional, longitudinal, and rehabilitation interventions), study design (e.g., experimental design and case series), sample characteristics, and gait and balance measurements.ResultsEighteen gait and balance (16 cross-sectional and 4 longitudinal) and 14 rehabilitation intervention studies were included. Cross-sectional studies showed that people with PSP have impairments in gait initiation and steady-state gait using wearable sensors, and in static and dynamic balance assessed by posturography when compared to Parkinson’s disease (PD) and healthy controls. Two longitudinal studies observed that wearable sensors can serve as objective measures of PSP progression, using relevant variables of change in turn velocity, stride length variability, toe off angle, cadence, and cycle duration. Rehabilitation studies investigated the effect of different interventions (e.g., balance training, body-weight supported treadmill gait, sensorimotor training, and cerebellar transcranial magnetic stimulation) on gait, clinical balance, and static and dynamic balance assessed by posturography measurements. No rehabilitation study in PSP used wearable sensors to evaluate gait and balance impairments. Although clinical balance was assessed in 6 rehabilitation studies, 3 of these studies used a quasi-experimental design, 2 used a case series, only 1 study used an experimental design, and sample sizes were relatively small.ConclusionWearable sensors to quantify balance and gait impairments are emerging as a means of documenting progression of PSP. Robust evidence for improving balance and gait in PSP was not found for rehabilitation studies. Future powered, prospective and robust clinical trials are needed to investigate the effects of rehabilitation interventions on objective gait and balance outcomes in people with PSP.

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Section: Effect Of Rehabilitation Interventions On Clinical Balance I...mentioning

confidence: 99%

Section: Effect Of Rehabilitation Interventions On Clinical Balance I...mentioning

confidence: 99%

Section: Frontiersinorgmentioning

confidence: 99%

Section: Frontiersinorgmentioning

confidence: 99%

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Balance and gait in progressive supranuclear palsy: a narrative review of objective metrics and exercise interventions

et al. 2023

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“…Transcranial alternating current stimulation (tACS) is a noninvasive brain stimulation (NIBS) method that uses sinusoidal alternating electric currents to affect cortical oscillatory neuronal activity. tACS synchronizes brain oscillations, induces long-term synaptic plasticity, and promotes functional recovery in patients with neurological diseases (Fröhlich and McCormick, 2010 ; Ozen et al, 2010 ; Reato et al, 2010 ; Ali et al, 2013 ; Koganemaru et al, 2018 , 2019 , 2020 ; Negahbani et al, 2018 ; Nojima et al, 2023 ; Shima et al, 2023a , b ).…”

Section: Introductionmentioning

confidence: 99%

Case report: An N-of-1 study using amplitude modulated transcranial alternating current stimulation between Broca's area and the right homotopic area to improve post-stroke aphasia with increased inter-regional synchrony

Omae,

Shima,

Tanaka

et al. 2024

Front. Hum. Neurosci.

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Over one-third of stroke survivors develop aphasia, and language dysfunction persists for the remainder of their lives. Brain language network changes in patients with aphasia. Recently, it has been reported that phase synchrony within a low beta-band (14–19 Hz) frequency between Broca's area and the homotopic region of the right hemisphere is positively correlated with language function in patients with subacute post-stroke aphasia, suggesting that synchrony is important for language recovery. Here, we employed amplitude-modulated transcranial alternating current stimulation (AM-tACS) to enhance synchrony within the low beta band frequency between Broca's area and the right homotopic area, and to improve language function in a case of chronic post-stroke aphasia. According to an N-of-1 study design, the patient underwent short-term intervention with a one-time intervention of 15 Hz-AM-tACS with Broca's and the right homotopic areas (real condition), sham stimulation (sham condition), and 15 Hz-AM-tACS with Broca's and the left parietal areas (control condition) and long-term intervention with sham and real conditions (10 sessions in total, each). In the short-term intervention, the reaction time and accuracy rate of the naming task improved after real condition, not after sham and control conditions. The synchrony between the stimulated areas evaluated by coherence largely increased after the real condition. In the long-term intervention, naming ability, verbal fluency and overall language function improved, with the increase in the synchrony, and those improvements were sustained for more than a month after real condition. This suggests that AM-tACS on Broca's area and the right homotopic areas may be a promising therapeutic approach for patients with poststroke aphasia.

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Comparative Effects of Core Stability Exercises and Retro-walk on Balance and Coordination in Down Syndrome

Ur Rehman Cheema,

Hafeez,

Mannan

et al. 2023

JHRR

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Background: Individuals with Down syndrome (DS) often face motor deficits impacting balance and coordination. While core stability exercises are a recognized form of intervention, the potential benefits of Retro walking require further exploration. Objective: To evaluate and compare the effects of core stability exercises and Retro walking on balance and coordination in individuals with DS. Methods: This randomized clinical trial included 24 participants with a confirmed diagnosis of DS, aged 8-14 years, and with mild to moderate mental retardation. They were allocated into two groups: Group A, receiving core stability exercises, and Group B, undergoing Retro walking, both over an 8-week period. Inclusion criteria were the ability to stand and walk with a Pediatric Balance Scale (PBS) score of at least 14/56. Exclusion criteria encompassed any orthopedic, cardiac, or uncontrolled cardiovascular conditions. Assessments were conducted using the PBS and Foot Tapping Test, pre- and post-intervention. Data analysis was performed using SPSS version 25.0, employing paired and independent t-tests. Results: Post-intervention, Group A exhibited an increase in PBS scores from 15.83±2.406 to 32.17±2.209 (p < .001), and Group B from 15.08±2.999 to 31.25±1.913 (p < .001). Foot Tapping Test scores for the right side improved from 9.92±1.311 to 20.17±2.082 in Group A (p < .002), and from 9.67±1.614 to 18.08±2.610 in Group B (p < .003). Conclusion: Both core stability exercises and Retro walking significantly improved balance and coordination in children with DS. These modalities should be considered valuable additions to the therapeutic interventions for this population.

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Case report: Backward gait training combined with gait-synchronized cerebellar transcranial alternating current stimulation in progressive supranuclear palsy

Cited by 3 publications

References 62 publications

Balance and gait in progressive supranuclear palsy: a narrative review of objective metrics and exercise interventions

Balance and gait in progressive supranuclear palsy: a narrative review of objective metrics and exercise interventions

Case report: An N-of-1 study using amplitude modulated transcranial alternating current stimulation between Broca's area and the right homotopic area to improve post-stroke aphasia with increased inter-regional synchrony

Comparative Effects of Core Stability Exercises and Retro-walk on Balance and Coordination in Down Syndrome

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