Case Report: Clonorchis sinensis Infection Associated with Eosinophilic Pneumonia

Reddy, Archana; Chakrabarty, Melony; Liu, Ying; Cohen, Stuart H.; Maniar, Archana

doi:10.4269/ajtmh.20-0632

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…CS, a trematode prevalent in East Asia especially in China that accounts for one third of total CS infection number. Exposure typically occurs through ingestion of raw or undercooked fresh water sh?shrimp containing the encysted larval form of the parasite [3] . As a matter of fact, other unhealthy behavior, for example, undesirablely eating the cooked foods that are possibly contaminated by chocking block, also transfers CS spreading.…”

Section: Discussionmentioning

confidence: 99%

An Increasingly Growing Cyst of the Left Liver with Plenty of Small-Sized Nodules of the Cyst Lining Triggered by Chinese Clonorchiasis but Misdiagnosed as An Infectious Cystoadenocarcinoma: A Case Report

Zhong

Zhou

2023

Preprint

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Clonorchis Sinensis (CS), a trematode prevalent in East Asia, likes inhabiting the hepatobiliary tract, especially the left liver once mammal (a definitive host) such as human, cat, dog and pig accidentally eats raw or undercooked fresh water fish/shrimp contaminated by the encysted larval, this coonosis could result in bile stasis favoring bacterial growing. Liver cyst formation due to intrahepatic tract obstruction, and even cholangiocarcinoma transformation. However, liver cyst with plenty of nodules of cyst lining resulting from CS infection is seldom reported, and is easy to be misdiagnosed as cystadenoma or even cystadenocarcinoma especially in a big city without any epidemic parasite. Herein, we describe an unusual case of an infectious liver cyst with multiple nodules mimicking as cystadenocarcinoma. The patient was a 55-year-old man from China who complained of months of anorexia, malaise, and a few days of fever. Enhanced computed tomography (CT) of the abdomen revealed a huge cyst of left liver with plenty of nodules of cyst lining, containing a large amount of fine-tiny, high-dense contents and unclear cyst fluid. An infectious cystadenocarcinoma was surmized in combination with high blood neutrophilia,C-reactive protein (CRP),and high erythrocyte sedimentation rate (ESR), and high carcinoembryonic antigen (CEA) level in cyst fluid. Furthermore, no parasitic eggs in stool and left hepatobiliary tract by biopsy and drainage were observed under microscopy prior to surgery. The infectious cyst was well-controlled by 3 weeks of administration of antibiotics and continuative drainage of cyst fluid until the inflammatory markers were back to normal and the cyst volume was no longer reduced, and then left hemihepatectomy with a close cyst was performed. unexpectedly, a final conclusion of CS associated with liver cyst and granunomas of cyst lining was made on postoperative pathology. Therefore, the patient proceeded to standard flukecide therapy (3 days of praziquantel oral intake). Due to large population mobility and eating habit of local resident in developing countries, people might become an infection resource that could be walkable around. Detail-oriented radiological characteristics of CS infection associated cyst formation would be favorable for early identification, in combination with typical symptoms and high CRP and ESR especially when no evidence of CS eggs or adult worm bodies are provided.

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Section: Discussionmentioning

confidence: 99%

An Increasingly Growing Cyst of the Left Liver with Plenty of Small-Sized Nodules of the Cyst Lining Triggered by Chinese Clonorchiasis but Misdiagnosed as An Infectious Cystoadenocarcinoma: A Case Report

Zhong

Zhou

2023

Preprint

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“…Clonorchis sinensis is a trematode with a high prevalence in East Asia that can cause hepatobiliary infection (1). Clonorchis sinensis is mainly prevalent in China, South Korea, northern Vietnam and parts of Russia (2,3).…”

Section: Introductionmentioning

confidence: 99%

Clonorchis sinensis infection in a non‑endemic area: A case report

Chen,

He,

Tan

et al. 2024

Exp Ther Med

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Non-endemic Clonorchis sinensis infection is challenging to diagnose. The present study reports the case of a 40-year-old female patient with severe epigastric pain, initially suspected to be a liver lesion, who was admitted to The Affiliated Hospital of Zunyi Medical University (Zunyi, China). A combination of diagnostic procedures, including computed tomography and magnetic resonance imaging, revealed an abnormality in the left hepatic lobe. Postoperative evaluation and the epidemiologic history of the patient (consumption of raw fish slices) revealed characteristics of Clonorchis sinensis infection, including chronic bile duct inflammation and eosinophilic liver infiltration. The present case highlights the unexpected emergence of this disease outside of recognized endemic areas and advocates clinical vigilance. Even in non-endemic areas, individuals should be reminded not to eat raw fish and shrimp.

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“…The WHO has declared liver fluke to be an important biological carcinogenic factor [4][5][6]. The disease is prevalent in several Asian countries, including China, South Korea, Vietnam, Thailand, and the Russian Far East, among others.…”

Section: Introductionmentioning

confidence: 99%

A Case of Clonorchiasis in a Non-endemic Region of China

Li,

Ren,

Wang

et al. 2024

Cureus

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Clonorchiasis, an important foodborne parasitic disease, is prevalent in several Asian countries. In China, the three provinces with the highest incidence are Guangdong, Guangxi, and Heilongjiang, with no reported cases in Qingdao for nearly a decade. In this study, a 29-year-old male patient was diagnosed with fatty liver due to abnormal liver function during physical examination and was admitted to the hospital multiple times for examination and treatment within 3 years, but his liver function did not improve. Eventually, clonorchis eggs were found in the stool, confirming the diagnosis of clonorchiasis. The purpose of this report is to enhance the understanding of clonorchiasis among clinicians in no-prevalence areas, to familiarize laboratory technicians with egg identification, to strengthen parasite-knowledge training, and to reduce missed and misdiagnosed cases.

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Case Report: Clonorchis sinensis Infection Associated with Eosinophilic Pneumonia

Cited by 7 publications

References 14 publications

An Increasingly Growing Cyst of the Left Liver with Plenty of Small-Sized Nodules of the Cyst Lining Triggered by Chinese Clonorchiasis but Misdiagnosed as An Infectious Cystoadenocarcinoma: A Case Report

An Increasingly Growing Cyst of the Left Liver with Plenty of Small-Sized Nodules of the Cyst Lining Triggered by Chinese Clonorchiasis but Misdiagnosed as An Infectious Cystoadenocarcinoma: A Case Report

Clonorchis sinensis infection in a non‑endemic area: A case report

A Case of Clonorchiasis in a Non-endemic Region of China

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