Case Report: First Report of Autochthonous Human Cutaneous Myiasis Caused by Hypoderma lineatum in Europe

Rappelli, Paola; Varcasia, Antonio; Vargiu, Arnoldo; Scala, Antonio

doi:10.4269/ajtmh.18-0100

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…According to data presented by Hassan et al [ 15 ], the most common species of Hypoderma are H. bovis and H. lineatum when it comes to domestic cattle. H. bovis is frequently reported in countries from the northern hemisphere, and its pathogeny is of greater importance to farmers, considering the severity of lesions that this infection might induce if treatment is not instituted promptly (when first-stage larvae are in the peri-rachidian channel, in the absence of treatment, they might induce paralysis of the hind quarters) [ 13 ]. The results of the morphological identification doubled by PCR assays based on mitochondrial COI sequencing for the identification of H. bovis [ 28 ] performed during our study revealed the presence of H. bovis with two haplotypes: HB3 and HB8.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence rate of parasitism with H. bovis resulting from this study is fairly low compared with previously conducted studies, which reported prevalence rates between 32 and 43%, [16,17], 16.21% in Southern Romania [18]or with other countries: up to 85% in Italy [19,20], 67% in Turkey, 23% in Iraq [21], 43% in Belgium, 40% in France, 37.4% in Greece [22], 52.3% in Spain, 16% in Poland, 20% in Switzerland, up to 80% in China [23], and 31.1% in Albania [24]. The prevalence rate recorded 25 (2-7) 48 (6)(7)(8)(9)(10)(11)(12)(13)(14) 20 (1-5) 23 (5)(6)(7)(8)(9)(10) 106 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) May (Max-Min) June (Max-Min) p value equals 0.5861 By conventional criteria, this difference is considered to be not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…are rare, especially in Europe. However, in one case report, a farmer who had never travelled outside Italy was presented with an H. lineatum infection, confirmed by molecular analysis [ 13 ]. Puente et al (2010) [ 14 ] reported an H. sinense infection in a citizen who presented with abdominal pain and inflammation of the right inguinal and testicular area after travelling to northern India.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological Surveillance of Hypodermosis in Cattle from Romania

Dărăbuș,

Tomoioagă,

Florea

et al. 2023

Pathogens

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Hypodermosis, or warble fly, is an endemic parasitic disease, common in countries from the northern hemisphere. The use of effective insecticides has decreased the frequency of this parasitic disease, with untreated cattle remaining to act as reservoirs. This study focused on assessing the status of hypodermosis in northwestern Romania by means of clinical examination (skin inspection and palpation performed in order to identify nodules) conducted on a number of 11.741 cattle. The study was carried out from March until June 2021. The identified larvae were subject to molecular assays for species identification and genotyping, followed by comparison with data available in the GenBank database. The average prevalence rate of parasitism caused by Hypoderma spp. was 0.31%, with values ranging from a minimum of 0.11% to a maximum of 1.32%. The dominant age group among positive animals was the 1–3 years old category and in terms of breed distribution, most positive cases were seen in cows belonging to an indigenous breed: Bruna de Maramures. April was the most prolific month in terms of nodule count/animal. The species identified in our study by means of molecular assays was H. bovis with two haplotypes: HB3 and HB8.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiological Surveillance of Hypodermosis in Cattle from Romania

Dărăbuș,

Tomoioagă,

Florea

et al. 2023

Pathogens

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“…Based on the available information, H. bovis appears to be more dominant in central, eastern and northern Europe. Hypoderma lineatum , however, seems to be the predominant species in North America and southern Europe [9, 10] where it has been rarely reported to infest humans causing creeping subdermal myiasis [11–13] as the host specificity is not absolute.…”

Section: Introductionmentioning

confidence: 99%

LONGRANGE® (eprinomectin 5% w/v extended-release injection) efficacy against Hypoderma lineatum in an endemic area in southern Italy

et al. 2019

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Background Despite intensive control measures including governmental campaigns using highly-efficacious systemic insecticides, there is evidence for persisting or recurring bovine Hypoderma species populations in parts of Europe, the USA and Canada. The present study evaluated the efficacy of LONGRANGE® (eprinomectin 5% w/v extended-release injection) against the infestation of cattle with Hypoderma lineatum , which is considered to be the predominant bovine warble fly in southern Europe and in North America. Methods Thirty-six local breed cattle sourced in an endemic area in southern Italy and confirmed positive for Hypoderma exposure by ELISA were randomly assigned to three groups of 12 animals each. Cattle of one group served as control and received saline injectable solution, whereas those in the two other groups received LONGRANGE® by subcutaneous injection. LONGRANGE® was administered once, either when Hypoderma larvae were expected to be first-instars (L1) or after warbles development, with Hypoderma larvae moulting to the second-(L2) and third-(L3) instars. Cattle were checked at intervals for warbles and Hypoderma larvae were collected, examined for their viability and morphologically identified. The detection of Hypoderma on cattle was terminated when warbles were no longer emerging. Results All intact larvae collected were identified as H. lineatum . No live larvae were collected from any animal treated with LONGRANGE® while live specimens were sampled from nine of the 12 control cattle (1 to 9 larvae per animal) ( P = 0.0001 at α = 0.05). LONGRANGE® treatment was well accepted and no adverse events related to treatment or other health problems were observed. Conclusions This study confirmed the continued ‘preventive’ (efficacy against migrating L1) and ‘therapeutic’ (efficacy against L2 and L3 in warbles) efficacy of LONGRANGE® against H. lineatum infestation of cattle under contemporary field conditions.

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“…In 2014, a case report was published, describing a farmer, who had never travelled outside Italy with an infestation by H. lineatum , confirmed by molecular analysis. 3 Puente et al. (2010) reported on a European with an H. sinense infestation, presenting with abdominal pain and, inflammation of the right groin and testicular region after traveling to northern India.…”

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confidence: 99%