CASE REPORT: Haemorrhagic colitis associated with royal jelly intake

Yasuda, Yoshikazu; Shibagaki, Keigo; Tsukada, Nobuhiro; Nagasu, Naoko; Inagaki, Yasutaka; Miyamoto, Kei; Сузукі, Осаму; Kiryu, Y

doi:10.1111/j.1440-1746.1997.tb00472.x

Cited by 26 publications

(18 citation statements)

References 13 publications

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“…In the literature, several cases of hemorrhagic colitis [31], asthma [32] and anaphylaxis [33] by ingestion of RJ have been reported. RJ should be considered as a causative allergen.…”

Section: Discussionmentioning

confidence: 99%

Effect of royal jelly ingestion for six months on healthy volunteers

Morita

Ikeda

Kajita

et al. 2012

Nutr J

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BackgroundRoyal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans.MethodsWe conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.ResultsThirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).ConclusionsSix-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

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“…In the literature, several cases of hemorrhagic colitis [31], asthma [32] and anaphylaxis [33] by ingestion of RJ have been reported. RJ should be considered as a causative allergen.…”

Section: Discussionmentioning

confidence: 99%

Effect of royal jelly ingestion for six months on healthy volunteers

Morita

Ikeda

Kajita

et al. 2012

Nutr J

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“…Since the maximum mucosal damage caused by MTX occurs after 72 hours (Yonei et al, 1997),, on the 11 th day 72 hours after the MTX administration, all the rats were sacrificed under general anesthesia (50 mg/kg ketamine ip). Just before they were sacrificed, 4-5 cc blood samples were obtained from each rat by intracardiac puncture and centrifuged at 3000 rpm for 10 minutes and the plasma was separated.…”

Section: The Way That the Samples Obtained And Their Storagementioning

confidence: 99%

Efficacy of royal jelly on methotrexate-induced systemic oxidative stress and damage to small intestine in rats

Kaynar¹,

Çetin²,

Hacioglu³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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The aim of this present study is to investigate the mucositis caused by methotrexate (MTX), as well as whether the application of royal jelly (RJ) has a protective effect on oxidative stress. This present study included six groups each consisted of 12 Wistar rats. Distilled water (po: peroral) was given to the 1 st group as placebo for 10 days and MTX (20 mg/kg, intraperitoneal: ip) on the 7 th day. The 2 nd group received RJ (50mg/kg, po) for 10 days and normal saline (NS) instead of MTX. RJ (50mg/kg) was given to the 3 rd group for 10 days and MTX on the 7 th day. The 4 th group received RJ (100 mg/kg, po) for 10 days and NS was given intraperitoneally. RJ (100mg/kg) was given to the 5 th group for 10 days and a single dose of MTX. Distilled water was given to the 6 th (control) group for 10 days and intraperitoneal NS on the 7 th day. Malondialdehyde (MDA), glutathione peroxidase and superoxide dismutase were analyzed in blood samples on the 11 th day. Morphological and histopathological changes were examined in the intestinal tissue samples. Villus length and mucosal thickness, as well as the villus length/crypt ratio, were significantly decreased with MTX administration, and the semiquantitative histological evaluation (SQHE) score was measured high (p<0.001). In addition, a decrease in the antioxidant parameters and an increase in the MDA levels were identified. The villus length and SQHE were significantly different in the groups receiving RJ (p<0.001) as compared to the MTX group. Although RJ addition had no effect on the decreased mucosal thickness and villus/crypt ratio in MTX groups, it caused an improvement in the antioxidant levels and a remarkable decrease in MDA levels. Adding RJ has a decreasing effect on the MTX-induced intestinal damage and it has a suppressive effect on MTX-induced oxidative stress by means of increasing antioxidant enzyme activity and decreasing lipid peroxidation.

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“…Une revue de la littérature nous a permis de colliger plus d'une trentaine de cas d'allergie à la gelée royale [5,13,15,25,28,30,31,36,37,40,43,45,46,48,49].…”

Section: Symptoˆmes Et Diagnosticunclassified

“…D'autres auteurs ont rapporté une gastroentérite à éosinophiles [36] et une colite hémorragique [49] ; -une femme de 28 ans, asthmatique depuis l'âge de trois ans, devait développer un asthme aigu grave avec anaphylaxie après la quatrième injection d'Abiocef ® (cefonicid). Toutefois, il apparut que la patiente avait consommé de la gelée royale avant chaque injection intramusculaire de cefonicid [46].…”

Section: Symptoˆmes Et Diagnosticunclassified

Allergies au miel et aux produits de la ruche

Dutau¹

2009

Phytothérapie

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Les produits de la ruche comportent un grand nombre d'allergènes provenant du corps des abeilles et des produits qu'elles récoltent (pollens, nectar, propolis) et fabriquent (miel, gelée royale). Si les IgE du sérum des allergiques aux abeilles sont capables de fixer un grand nombre de protéines du miel, la prévalence de l'allergie au miel est faible chez les allergiques aux hyménoptères ou chez les apiculteurs. En revanche, l'allergie aux pollens en particulier de Composées (armoise, camomille, pissenlit) constitue un facteur de risque d'allergie au miel et à la gelée royale. L'éviction des produits en cause est la seule parade. Toutefois, le miel et les pollens, et à un degré moindre la gelée royale, sont souvent masqués dans les produits alimentaires, diététiques et énergétiques. Il faut aussi se méfier des compositions d'herboristerie non étiquetées. Une surveillance des accidents allergiques au miel, à la gelée royale et à la propolis est indispensable.

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CASE REPORT: Haemorrhagic colitis associated with royal jelly intake

Cited by 26 publications

References 13 publications

Effect of royal jelly ingestion for six months on healthy volunteers

Effect of royal jelly ingestion for six months on healthy volunteers

Efficacy of royal jelly on methotrexate-induced systemic oxidative stress and damage to small intestine in rats

Allergies au miel et aux produits de la ruche

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