Case report lymphoepithelial cyst of the pancreas with sebaceous differentiation

Fitko, Rosanne; Kampmeier, Patricia A.; Batti, Fawzia; Benjoya, Ross A.; Rao, Sambasiva

doi:10.1007/bf02924665

Cited by 26 publications

(1 citation statement)

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“…The present study detected various combinations of epithelial cells by marker expression : squamous cell, pancreatic duct cell, and sebaceous gland. Although sebaceous gland differentiation of squamous epithelium has been indicated in several reports of lymphoepithelial cyst in the pancreas (31,32), the presence of variable epithelial cells in individual ECIPAS is not consistent with epithelial cells arising from metaplastic changes of pancreatic duct cells. Smooth muscle in the cyst wall was also detected ; since a layer of smooth muscle does not surround the pancreatic duct, the origin of smooth muscle cannot be explained by invagination of the pancreatic duct.…”

Section: Discussionmentioning

confidence: 87%

Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

et al. 2023

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Background : Epidermoid cysts in intrapancreatic accessory spleen (ECIPAS) are a rare lesion. Its pathogenesis, including the origin of cystic epithelium, is not well established. We aimed to elucidate new aspects of the pathological features of ECIPAS to clarify its pathogenesis. Methods : Six cases of ECIPAS were included in this study. As well as histopathological analysis, to elucidate the features and nature of cystic epithelial cells, immunohistochemical analysis including Pbx1 and Tlx1 and imaging mass spectrometry was performed. Results : Histologically, the cysts were covered by either monolayered or multilayered epithelium. Immunohistochemistry revealed that the epithelial cells in multilayered epithelium exhibited different attributes between the basal and superficial layers. Few epithelial cells had abundant clear cytoplasm and were immunohistochemically positive for adipophilin, suggesting lipid-excreting function. The intracystic fluid contained cholesterol clefts and foamy macrophages, and imaging mass spectrometry revealed the accumulation of lipids. Immunohistochemical analysis indicated that the epithelial cells were positive for Pbx1 in some cases. Conclusion : Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin.

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Section: Discussionmentioning

confidence: 87%

Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

et al. 2023

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Lymphoepithelial cyst (lEC) of the pancreas: Cytomorphology and differential diagnosis on fine-needle aspiration (FNA)

1999

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Cyst Fluid Cytology and Chemical Features in a Case of Lymphoepithelial Cyst of the Pancreas: A Rare and Difficult Preoperative Diagnosis

Centeno

Stockwell²,

Lewandrowski

1999

Diagn. Cytopathol.

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Most pancreatic cysts (90%) are inflammatory pseudocysts. Approximately 10% of pancreatic cysts are neoplasms, including serous cystadenomas, and mucinous tumors, some of which are malignant. Analysis of pancreatic cyst fluid obtained by percutaneous or endoscopic fine‐needle aspiration is increasingly being used for the preoperative diagnosis of pancreatic or peripancreatic cysts. However, cyst fluid chemical and cytologic features in less common types of pancreatic cysts have not been reported. Lymphoepithelial cyst of the pancreas is exceedingly rare, and only occasional individual reports have described cyst fluid findings. We report on a case of lymphoepithelial cyst of the pancreas developing in a middle‐aged man. Cyst fluid aspirated under radiological guidance showed elevated levels of carcinoembryonic antigen (CEA), CA19‐9, CA 125, and amylase, and a viscosity greater than that of serum. A cell block preparation of a fine‐needle aspiration showed tissue fragments with a keratinized squamous lining and a lymphocytic infiltrate in the wall, and abundant background keratinous debris. The cytologic and biochemical findings in this case exhibit similarities to the findings reported in other reports, and may represent a recognizable pattern on cyst fluid analysis. Diagn. Cytopathol. 1999;21:328–330. © 1999 Wiley‐Liss, Inc.

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Case report lymphoepithelial cyst of the pancreas with sebaceous differentiation

Cited by 26 publications

References 7 publications

Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

Lymphoepithelial cyst (lEC) of the pancreas: Cytomorphology and differential diagnosis on fine-needle aspiration (FNA)

Cyst Fluid Cytology and Chemical Features in a Case of Lymphoepithelial Cyst of the Pancreas: A Rare and Difficult Preoperative Diagnosis

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