Case Report: Mammary and rectal metastases from an ovarian cancer: report of two cases and review of literature

Amzerin, Mounia; Garcia, Camilo; Stanciu, C; Veys, Isabelle; Awada, Ahmad; Errihani, Hassan; Gombos, Andrea

doi:10.12688/f1000research.2644.2

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…We identified previously published case reports of hematogenic colorectal metastasis from ovarian cancer through PubMed search, using "colon metastasis" and "ovarian cancer" as keywords. Only 7 cases of colorectal metastasis from ovarian cancer that appeared to have metastasized hematogenously have been reported, and their clinicopathological findings are summarized in Table 1 [1][2][3][4][5][6][7]. The metastasis site in all cases was in the left colon including the rectum.…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian cancer is the leading cause of cancer-related deaths among women with gynecological cancers. Although distant metastasis is the most common cause of death, colonic metastasis by hematogenous dissemination is extremely rare; only 7 cases have been reported [1][2][3][4][5][6][7]. Ovarian cancer tends to spread through direct invasion, intraperitoneal seeding, and lymphatic or hematogenous dissemination [1,8].…”

Section: Introductionmentioning

confidence: 99%

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Metastasis of Ovarian Cancer to the Descending Colon

Abe

Anzai

Eguchi

et al. 2023

Case Rep Gastroenterol

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Colonic metastasis from ovarian cancer is extremely rare, with only seven reported cases. A 77-year-old woman who had previously undergone surgery for ovarian cancer was admitted to a local hospital with anal bleeding. Histopathological analysis confirmed the presence of adenocarcinoma. Colonoscopy revealed a descending colon tumor. The patient was diagnosed with Union for International Cancer Control T3N0M0 descending colon cancer or colon metastasis of the ovarian cancer. Laparoscopic left colectomy was performed; intraoperative frozen section diagnosis confirmed metastasis from ovarian cancer, and the absence of invasion to the serosal surface suggested hematogenous metastasis. This is the first case of colonic metastasis from ovarian cancer that was diagnosed using an intraoperative frozen section and laparoscopically treated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metastasis of Ovarian Cancer to the Descending Colon

Abe

Anzai

Eguchi

et al. 2023

Case Rep Gastroenterol

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show abstract

“…In this series, the mean survival time was 12 months. Smaller series of MOCB have also described 5 ( 7 ), 4 ( 1 ), 3 ( 8 ), 2 ( 9 ), 1 ( 10 ), 1 ( 11 ), 1 ( 12 ), and 1 ( 13 ) cases, respectively.…”

Section: Introductionmentioning

confidence: 99%

Metastasis of ovarian cancer to the breast: A report of two cases and a review of the literature

Tempfer¹,

Fizazi²,

Ergonenc³

et al. 2016

Oncology Letters

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Metastasis of ovarian cancer to the breast (MOCB) is a rare event. Clinical presentations of MOCB vary and surgery is the mainstay of treatment. The current study presents two cases of MOCB in women with recurrent ovarian cancer first diagnosed in April 2011 and October 2013, respectively. The patients presented to the clinic with a localized, palpable, painful mass in the upper outer quadrant of the right breast and a centrally localized, palpable, painful mass of the left breast, respectively. Breast sonography and mammography showed a singular, round, homogenous tumor with irregular borders in each case. An ipsilateral enlarged axillary node was palpable in one case. Tumor biopsy revealed an undifferentiated adenocarcinoma of unknown origin in one case and a moderately-differentiated adenocarcinoma suspected to be breast cancer in the other case. Tumor cells were positive for estrogen receptor and paired box 8, and negative for GATA binding protein 3 in the two cases. Palliative mastectomy was performed in one case and lumpectomy with ipsilateral axillary sentinel node biopsy in the other case, and the final histology revealed MOCB in each. The post-operative course of the disease was uneventful and the patients continued with their ovarian cancer-specific chemotherapy. One patient succumbed to disease progression 2 months after breast surgery. The other patient remains alive and is currently undergoing systemic chemotherapy. The current study also presents a review of 110 cases of MOCB identified in a literature search of Pubmed. Data from these studies, including the clinical and histological characteristics of MOCB, and the clinical management and prognosis are discussed. Overall, MOCB is rare, with distinct clinical and histological features. The disease is usually treated with local surgical excision or mastectomy and has a poor prognosis.

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Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

et al. 2020

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Although ovarian cancer often presents as a widespread disease, metastases to the breast and/or axillary lymph nodes are a very rare event, accounting for only 0.03–0.6% of all breast cancers. Its early recognition and accurate distinction from primary breast cancer are of crucial importance to choose an adequate systemic therapy over unnecessary surgeries. We presented the case of a 53-year-old woman who was diagnosed with breast metastases 2 years after the diagnosis of advanced primary serous ovarian cancer. The patient underwent primary cytoreductive surgery and platinum-based chemotherapy in combination with bevacizumab, followed by bevacizumab maintenance for 18 months. After 2 years of negative follow-ups, the disease unexpectedly spread to the left breast and axillary lymph nodes. No axillary lymph node dissection or breast surgery was performed. The patient received axillary radiotherapy and multiple chemotherapy lines: gemcitabine/cisplatin, liposomal doxorubicin, topotecan, olaparib/cediranib, paclitaxel, and cisplatin. Unfortunately, none of these treatments improved her prognosis and she died 3 years after the disease recurrence. Ovarian cancer metastasis to the breast reveals a disseminated disease with a poor prognosis. Currently, no valid treatment options are available as the disease shows multidrug chemoresistance. In the era of precision medicine, the characterization of genetic and molecular markers may play a role in offering new promising targeted therapies.

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Case Report: Mammary and rectal metastases from an ovarian cancer: report of two cases and review of literature

Cited by 4 publications

References 17 publications

Metastasis of Ovarian Cancer to the Descending Colon

Metastasis of Ovarian Cancer to the Descending Colon

Metastasis of ovarian cancer to the breast: A report of two cases and a review of the literature

Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

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