Case Report on Leiomyosarcoma of the Vulva:  A Rare Pathology

Smith, Samantha A; Zgheib, Nadim Bou; Vallejos, Andrea M; Cuda, Jonathan D.

doi:10.33470/2379-9536.1294

Cited by 4 publications

(9 citation statements)

References 6 publications

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“…Of the 26 cases of VLMS reported in the literature, 6 patients underwent a LND, although imaging suggested possible lymph node metastases in the bilateral external iliac lymph nodes in only 1 case ( Table 3 ) [ 36 ]. In 5 of these 6 cases, an inguinal LND was performed, and in 1 case an inguino-femoral LND was performed [ 43 ]. The inguino-femoral LND was done bilaterally, and 4 of the 5 inguinal LND were done ipsilaterally.…”

Section: Discussionmentioning

confidence: 99%

“…Information on the side of the LND was missing in 1 case [ 51 ]. No lymph node metastases were detected in any of these 6 cases [ 33 , 36 , 43 , 45 , 49 , 51 ]. Information on follow-up was provided for 4 of the 6 patients with LND [ 36 , 45 , 49 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…She developed local recurrence after 12 months [ 45 ]. Details on the radiation dose or CHT regimen of the other patient were not provided [ 43 ]. The tumor size, however, was 8.0cm, and the patient remained recurrence-free after a follow-up period of 21 months [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

et al. 2023

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Case series Patients: — Final Diagnosis: Vulvar leiomyosarcoma Symptoms: Vulvar mass • vulvar pain • vulvar swelling Clinical Procedure: — Specialty: Obstetrics and Gynecology • Oncology Objective: Rare disease Background: Leiomyosarcomas of the vulva (VLMS) are very rare among gynecological malignancies, with a lack of knowledge on clinical presentation, prognosis, and therapeutic management. Case Reports: The database of the German Clinical Center of Competence for Genital Sarcomas and Mixed Tumors in Greifswald (DKSM) was reviewed between the years 2010 and 2020. A total of 8 cases of VLMS were retrieved and analyzed retrospectively. One exemplary case of VLMS was outlined in detail: A 45-year-old premenopausal woman presented with increasing vulvar swelling and discomfort. Given the suspicion of a Bartholin’s gland abscess, the mass was excised. Final pathology revealed a solid tumor consistent with a moderately differentiated leiomyosarcoma of the vulva. A wide local excision was subsequently performed followed by adjuvant external beam radiation. The clinical features of these 8 cases of VLMS were compared to 26 cases of VLMS found in a review of the literature and to a total of 276 cases of uterine leiomyosarcoma (ULMS) from the same database (DKSM). Conclusions: In addition to rapid growth, observed in both tumor entities, VLMS most commonly presented as Bartholin’s gland abscess or cyst and ULMS as leiomyoma. In this cohort, the prognosis of VLMS was much better than that of ULMS, most probably due to the significantly smaller tumor size of VLMS at diagnosis. Further data and larger studies on VLMS are needed to calculate recurrence and survival rates more accurately and define the role of adjuvant radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

et al. 2023

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“…Additional measures may include hemivulvectomy, ipsilateral inguinal lymphadenectomy radiation, or chemotherapy at the discretion of the oncologist. The necessity of adjuvant therapy is unknown currently [5,7,9,16]. The local recurrence and frequency of metastasis by the hematogenous route are high with a very aggressive nature and poor prognosis, However, the course of the disease and late recurrence are still not clear [11].…”

Section: Discussionmentioning

confidence: 99%

Vulvar Leiomyosarcoma in Pregnancy

Aljehani¹,

Quatei²,

Qattea³

et al. 2021

Cureus

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Vulvar leiomyosarcoma is a rare smooth muscle malignant neoplasm but it is the commonest type of vulvar sarcomas. It may mimic benign tumors and misdiagnosis could delay proper management. We report a case of a 38-year-old pregnant woman with leiomyosarcoma of the vulva. The patient presented to her primary general practitioner with a small vulvar mass that she had first noticed one year prior. The tumor was suspected to be benign Bartholin's cyst and treated with antibiotics. The patient declined improvement and had many consultations to different clinics where she had been diagnosed and treated the same. The tumor size started to grow rapidly after she got pregnant, and the patient was referred to our hospital where she underwent tumor resection. Histopathology revealed leiomyosarcoma. The patient had further assessment and close follow-up and has had no recurrence for 12 months. There is little literature available on vulvar leiomyosarcoma, most of which are case reports, and most gynecologic oncologists will go through their whole careers without seeing a single case.

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“…The histomorphological features and immunoprofile were consistent with leiomyosarcoma grade 2, according to the French Federation of Cancer Centers Sarcoma Group grading system. 2 , 5 …”

Section: Dear Editormentioning

confidence: 99%

Letter in Reply: Leiomyosarcoma of the Vulva Mimicking as Chronic Bartholin Cyst: A Case Report

Saquib¹,

Keloth²

2021

Oman Med J

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We appreciate the author’s positive comments about our article published in the July 2020 issue of the Oman Medical Journal. We agree with your suggestion to include pre- and intraoperative and macroscopic figures to give more information and knowledge for the readers. Our patient gave us consent to publish the case, understanding that it is a very rare pathology. From an ethical point of view and to respect the patients’ autonomy and confidentiality, we submitted only microscopic pictures as the diagnostic criteria of leiomyosarcoma.

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Case Report on Leiomyosarcoma of the Vulva: A Rare Pathology

Cited by 4 publications

References 6 publications

Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

Vulvar Leiomyosarcoma in Pregnancy

Letter in Reply: Leiomyosarcoma of the Vulva Mimicking as Chronic Bartholin Cyst: A Case Report

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