Vulvar Leiomyosarcoma in Pregnancy

Aljehani, Ala M; Quatei, Amani; Qattea, Lina; Aljohani, Renad M; Alkushi, Abdulmohsen

doi:10.7759/cureus.18772

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…In our case series, 66.7% of VLMS were initially misdiagnosed as a Bartholin’s gland abscess or cyst. When compared to the existing body of literature on VLMS, 7 of 11 cases were initially diagnosed as a Bartholin’s gland cyst or abscess (63.6%) ( Table 3 ) [ 33 , 34 , 37 , 38 , 45 , 46 , 49 ]. There was no information on the initial diagnosis in 15 of the 26 cases.…”

Section: Discussionmentioning

confidence: 99%

Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

et al. 2023

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Case series Patients: — Final Diagnosis: Vulvar leiomyosarcoma Symptoms: Vulvar mass • vulvar pain • vulvar swelling Clinical Procedure: — Specialty: Obstetrics and Gynecology • Oncology Objective: Rare disease Background: Leiomyosarcomas of the vulva (VLMS) are very rare among gynecological malignancies, with a lack of knowledge on clinical presentation, prognosis, and therapeutic management. Case Reports: The database of the German Clinical Center of Competence for Genital Sarcomas and Mixed Tumors in Greifswald (DKSM) was reviewed between the years 2010 and 2020. A total of 8 cases of VLMS were retrieved and analyzed retrospectively. One exemplary case of VLMS was outlined in detail: A 45-year-old premenopausal woman presented with increasing vulvar swelling and discomfort. Given the suspicion of a Bartholin’s gland abscess, the mass was excised. Final pathology revealed a solid tumor consistent with a moderately differentiated leiomyosarcoma of the vulva. A wide local excision was subsequently performed followed by adjuvant external beam radiation. The clinical features of these 8 cases of VLMS were compared to 26 cases of VLMS found in a review of the literature and to a total of 276 cases of uterine leiomyosarcoma (ULMS) from the same database (DKSM). Conclusions: In addition to rapid growth, observed in both tumor entities, VLMS most commonly presented as Bartholin’s gland abscess or cyst and ULMS as leiomyoma. In this cohort, the prognosis of VLMS was much better than that of ULMS, most probably due to the significantly smaller tumor size of VLMS at diagnosis. Further data and larger studies on VLMS are needed to calculate recurrence and survival rates more accurately and define the role of adjuvant radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

et al. 2023

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“…Another study by Aljehani et al observed a frequency of menstrual irregularities in Saudi women of child bearing age after COVID-19 vaccination, mostly affecting the cycle duration and dysmenorrhea [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the COVID-19 Infection on Women's Menstrual Cycle: A Retrospective Study at Latifa Hospital, Dubai, United Arab Emirates

Aftab,

Fahad,

Al Hammadi

et al. 2023

Cureus

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Background The COVID-19 pandemic has affected all of us in one way or another. The menstrual cycle is a reflection of the female reproductive system, and it is influenced by various factors including stress and infections. Although there is little information available about how the COVID-19 pandemic has affected women's reproductive health, it has had a significant impact on women. Objective The main objective of our study is to identify if there are any menstrual disturbances following COVID-19 infection in women. Study design Our study is a retrospective study wherein 700 women recovering from COVID-19 infection were asked about any new menstrual disturbances after the infection. We collected the data using questionnaires and analyzed the data using Statistical Product and Service Solutions (SPSS, version 26) (IBM SPSS Statistics for Windows, Armonk, NY). Results Our study showed no dysmenorrhea in 90% of the participants, 81% reported no change in menstrual flow rate, a vast majority (93%) denied experiencing amenorrhea, only 4% reported a new onset of intermenstrual bleeding, and 1% reported postmenopausal bleeding. Conclusion There was no significant change in the participants’ menstrual cycle following COVID-19 infection.

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“… 35 LMS includes three subtypes: spindled, epithelioid, and myxoid. 36,37 There is a solitary mass, usually with a diameter of more than 5 cm, and circumscribed or infiltrative borders. The cut surface is soft or firm and fleshy white-tan-gray with variable hemorrhage, necrosis, and cystic change.…”

Section: Introductionmentioning

confidence: 99%

Common and uncommon lesions of the vulva and vagina on magnetic resonance imaging: correlations with pathological findings

et al. 2023

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Vulvar and vaginal lesions representing a wide spectrum of diseases in female lower genital tract diseases make up a small part of all gynecological etiologies. Many of them are rare etiologies and are reported in case-reports studies. Translabial and transperineal ultrasound are modalities of choice for the first evaluation of perineal lesions. MRI is usually performed to determine the etiology of the lesions and stage. Benign lesions of the vulva and vagina usually manifest as simple cystic (vestibular cyst or endometrioma) or solid lesions (leiomyoma or angiofibroblastoma), while malignancies usually appear as large, solid masses and fill into both vaginal and perineal area. Post-contrast images play an important role in establishing a differential diagnosis, however, some benign lesions can also exhibit a vivid enhancement. Knowledge about radiologic-associated pathological manifestations may aid clinicians in better understanding these pathologies, especially for some rare lesions, and making a proper diagnosis before invasive procedures.

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Vulvar Leiomyosarcoma in Pregnancy

Cited by 3 publications

References 13 publications

Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature

Effects of the COVID-19 Infection on Women's Menstrual Cycle: A Retrospective Study at Latifa Hospital, Dubai, United Arab Emirates

Common and uncommon lesions of the vulva and vagina on magnetic resonance imaging: correlations with pathological findings

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