Case report: Periosteal neurofibroma mimicking osteochondroma

Subperiosteal schwannomas of the femur

“…However, after demonstrating the solid nature of the lesions on the contrast-enhanced images, the possibility of neurogenic tumours was considered by the referral centre. periosteal new bone formation, unlike the current case [7,8].…”

Solitary Intraosseous Neurofibroma of the Frontal Bone -Case Report-

“…The most common location is the mandible, the mean age is 24 years, and the most common clinical symptom is swelling. 18) Very few cases of intraosseous neurofibroma have been reported at other sites, including single cases of periosteal and intramedullary lesion of the tibia, 11,22) intramedullary lesion of the femur 6) and the maxilla, 20) vertebral body lesion of the cervical spine, 25) and intramedullary lesion of the clavicle. 19) Ten cases of intraosseous neurofibroma showed evidence of NF.…”

“…MR imaging shows non-specific findings, so is not helpful for diagnosis. 2,6,22,23) Only one case was associated with osteosclerosis. 22) FDG-PET can evaluate the malignancy of neurofibroma.…”

“…2,6,22,23) Only one case was associated with osteosclerosis. 22) FDG-PET can evaluate the malignancy of neurofibroma. Benign neurofibroma can be distinguished from malignant peripheral nerve sheath tumor with about 100% sensitivity and 83% specificity using a SUV cut-off value of 1.8.…”

“…22) Neurofibroma of the bone is called intraosseous neurofibroma, and usually originates from the inferior alveolar nerve of the mandible, but also occurs in the long bones, such as the femur, tibia, and clavicle. The histological character and benign nature are similar to those of neurofibroma of the peripheral nerve.…”