Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor

Polat, Yalcin; Arslan, Gözde; Kebudi, Abud; Apa, Duygu Düşmez

doi:10.1016/j.ijscr.2018.10.038

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…CD34 is expressed in the stroma of phyllodes but is absent in spindle cell metaplastic carcinoma, fibromatosis, or liposarcoma. [ 4 ] Our case showed negative staining for pan-CK and CD 34 but was focally positive for S100. [ 9 ] Sarcomas are spread by direct local invasion or through a hematogenous route.…”

Section: Discussionmentioning

confidence: 89%

“…Pure sarcomas without pre-existing phyllodes are extremely rare, and it needs to be excluded. [ 4 ] In metaplastic carcinomas, the malignant epithelial component tends to merge with the spindle cell element, whereas in malignant phyllodes, the epithelial component is benign and is discrete from the spindle cell component. A panel of CK markers and p63 should be used to rule out metaplastic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…To diagnose primary liposarcoma of the breast, extensive sampling of the specimen is required. [ 3 4 ] Imaging modalities identify liposarcoma often as invasive breast carcinoma. Diagnosing the type of sarcoma and the degree of differentiation is important for surgical management and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Liposarcoma of Breast, Presenting as a Recurrent Breast Tumor

Zaheer

Aden²,

Saxena³

et al. 2022

Journal of Mid-Life Health

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Primary pleomorphic liposarcoma of the breast is a very rare mesenchymal tumor. Sarcoma arising in the breast constitutes <1% of all malignant breast tumors, and liposarcoma of the breast has an incidence of 0.3% of all mammary sarcomas. It is a very aggressive tumor with a high incidence of recurrences and distant metastasis. They can mimic primary invasive breast cancer clinically as well as radiologically. Histology and radiological evaluation of the patient help correctly type and grade this malignancy. On microscopy, the tumor is composed of pleomorphic tumor cells with atypical lipoblast with areas of necrosis and mitosis. We report one such rare case here.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pleomorphic Liposarcoma of Breast, Presenting as a Recurrent Breast Tumor

Zaheer

Aden²,

Saxena³

et al. 2022

Journal of Mid-Life Health

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Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists

Sars

Sackey

Frisell

et al. 2023

Breast Cancer Res Treat

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Purpose Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking. Methods We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents. Results A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types. Conclusions This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors.

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Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor

Cited by 2 publications

References 14 publications

Pleomorphic Liposarcoma of Breast, Presenting as a Recurrent Breast Tumor

Pleomorphic Liposarcoma of Breast, Presenting as a Recurrent Breast Tumor

Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists

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