Case report: Transformation of juvenile fibroadenoma to borderline phyllodes tumor in young lady

Abstract

Introduction Fibroadenoma is the most common benign tumor found in young women. Transformation for Fibroadenoma to borderline phyllodes tumor is rare. Phyllodes tumor tends to recur locally due to the aggressive nature of the phyllodes tumor tissue, which tends to become malignant when recurrence occurs. Presentation of case We report an 18-year-old woman with a lump in the right breast for one year, a mass in the upper lateral quadrant measuring 20x15x10cm; the lump felt mobile, supple, cystic. 2 years earlier, lumpectomy surgery with anatomical pathology of fibroadenoma mammae with 6 cm. A biopsy was performed, the result was a borderline phyllodes tumor. Neoadjuvant chemotherapy was performed with tumor reduction >50%, followed by wide excision surgery with tumor-free margins. The first one-year evaluation showed no signs of recurrence, and no signs of distant metastases were found. Conclusion Our patient had a juvenile relapse FA which progressively changed to borderline tumor phyllodes borderline. We report this case to the need for continuous follow-up for fibroadenoma cases and the possibility of recurrence and becoming malignant.

Bilateral Phyllodes in a 12-Year-Old Adolescent: Report of a Rare Case

“…On USG, it is difficult to differentiate between fibroadenoma and phyllodes as there are several overlapping features; however, phyllodes show more cystic areas than fibroadenoma on an USG [1,6,8]. One such case reported that juvenile fibroadenoma converted into a borderline phyllodes tumor in an 18-year-old [9]. A case of phyllodes in an 11-year-old girl from Mumbai and another in a 12-year-old from Chile were investigated to reveal that both of their USG and FNAC reports were suggestive of giant fibroadenoma [1,6].…”

A Rare Case of Invasive Ductal Carcinoma and Ductal Carcinoma In Situ Found Within Borderline Phyllodes Tumor

“…Rare cases have been reported of FA transformation to a borderline or malignant PT over time, which may also be the case in our patient. [8,9]Review of the initial CNB was rm in the diagnosis of a FA without indication of PT histological features. To our knowledge, there has only been 1 other case report published displaying a CNB-proven FA transformation to a PT with concomitant breast carcinoma.The authors of the case describe a 53-year-old female with a twice CNB-proven FA that progressed to bPT with components of tubular carcinoma and lobular carcinoma in situ.…”

Delayed Conversion of a Fibroadenoma Into a Large Phyllodes Tumor: A Case Report

“…The first case we identified described an 18-year-old female who had a relapsing juvenile fibroadenoma excised via lumpectomy. Despite surgical removal with sufficient margins, the breast lesion progressively recurred into a borderline phyllodes tumor over a one-year time period [ 8 ]. Another case was seen in a 40-year-old female who developed a malignant phyllodes tumor from a fibroadenoma over the course of three years, despite minimal changes in the overall breast mass size [ 9 ].…”