2009
DOI: 10.5551/jat.729
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Casein-Derived Tripeptide, Val-Pro-Pro (VPP), Modulates Monocyte Adhesion to Vascular Endothelium

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Cited by 68 publications
(47 citation statements)
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“…There have been some reports of food-derived peptides with vasoprotective activity. Recently, the effect of the milk casein-derived tripeptide valine-proline-proline (VPP) on monocyte adhesion to endothelium under flow conditions was examined in a phorbol 12-myristate 13-acetate (PMA)-stimulated human acute monocytic leukemia cell line (THP-1 cells) (Aihara et al, 2009). Pre-incubation of THP-1 cells with VPP significantly decreased the PMA-induced adhesion of THP-1 cells to HUVECs.…”
Section: Methodsmentioning
confidence: 99%
“…There have been some reports of food-derived peptides with vasoprotective activity. Recently, the effect of the milk casein-derived tripeptide valine-proline-proline (VPP) on monocyte adhesion to endothelium under flow conditions was examined in a phorbol 12-myristate 13-acetate (PMA)-stimulated human acute monocytic leukemia cell line (THP-1 cells) (Aihara et al, 2009). Pre-incubation of THP-1 cells with VPP significantly decreased the PMA-induced adhesion of THP-1 cells to HUVECs.…”
Section: Methodsmentioning
confidence: 99%
“…VPP or IPP) on BP are evident in Asian patients and seem to be independent of age and dose; in these populations observed average decreases in systolic BP (SBP) and DBP are around 5 mm Hg and 2 mm Hg, respectively and have no health impact (Cicero et al, 2010); so, the European Food Safety Authority (EFSA) rejected a health claim on the effect of IPP and VPP on BP (EFSA Panel on Dietetic Products, Nutrition and Allergies, 2012). Concerning the use of fermented mik-containing BioPep, yet there is limited but consistent evidence that their consumption improves arterial stiffness and prevents adhesion of inflammatory molecules to endothelium surface (Aihara et al, 2009;Pase et al, 2011). A recent Cochrane review concluded that they have a modest effect on SBP, and no evident effect on DBP.…”
Section: Accepted Manuscriptmentioning
confidence: 97%
“…In vivo BP regulation is a highly regulated homeostasis which involves other mechanisms than ACE, via vasoactive molecules, which could also be found as by-products in fermented foods (Teschemacher, 2003;Aihara et al, 2009;Tidona, et al, 2009;Ballard, et al,. 2012).…”
Section: Blood Pressurementioning
confidence: 99%
“…Aihara et al reported that VPP moderates adhesion of monocytes to the inflamed endothelium, which is the first step in the formation of an atherosclerotic plaque. 25) Furthermore, the addition of VPP and IPP to a culture medium of human umbilical vein endothelial cells (HUVEC) caused elevation of the cellular NOx concentration, and these peptides induced endothelium-dependent relaxation of isolated aortic rings in the rat. 26) In clinical studies, continuous intake of casein hydrolysate containing VPP and IPP has been found to improve hemodynamic parameters such as central SBP, the augmentation index (AI), and maximum blood flow during reactive hyperemia.…”
Section: Discussionmentioning
confidence: 99%