Casein phosphopeptide-amorphous calcium phosphate in dentistry: An update

Divyapriya, GK; Yavagal, Puja C; Veeresh, DJ

doi:10.4103/2231-6027.186660

Cited by 33 publications

(22 citation statements)

References 2 publications

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“…One hypothesis invoked to explain the antibacterial properties of these complexes refers to their ability to adhere to dental biofilm, interfere with the binding capacity of the bacteria, 10 and also induce high intracellular free calcium ion concentrations. 11 Another possibility is that hydroxylated CP nanoparticles, such as HAp and some ACPs, act in a merely bacteriostatic fashion, thanks to their "smart" solubility in direct proportion with the acidity of the medium 12 and acidneutralization capacity, 13 thus restricting the conditions for the growth of bacteria, including S. mutans and S. aureus, which favor mildly acidic conditions over the physiological ones. 14,15 Multiple other possibilities could be proposed, including the disruptive cell membrane effect of CP nanoparticles or Posner's clusters, 16 9 Å sized, heavily hydrated, and nonequilibrium CP units forming the building blocks of CP nuclei and presumably constantly separating from and reintegrating with the CP surface in an aqueous medium.…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: In search of the key particle property

et al. 2019

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One of the main goals of materials science in the 21st century is the development of materials with rationally designed properties as substitutes for traditional pharmacotherapies. At the same time, there is a lack of understanding of the exact material properties that induce therapeutic effects in biological systems, which limits their rational optimization for the related medical applications. This study sets the foundation for a general approach for elucidating nanoparticle properties as determinants of antibacterial activity, with a particular focus on calcium phosphate nanoparticles. To that end, nine physicochemical effects were studied and a number of them were refuted, thus putting an end to frequently erred hypotheses in the literature. Rather than having one key particle property responsible for eliciting the antibacterial effect, a complex synergy of factors is shown to be at work, including (a) nanoscopic size; (b) elevated intracellular free calcium levels due to nanoparticle solubility; (c) diffusivity and favorable electrostatic properties of the nanoparticle surface, primarily low net charge and high charge density; and (d) the dynamics of perpetual exchange of ultrafine clusters across the particle/solution interface. On the positive side, this multifaceted mechanism is less prone to induce bacterial resistance to the therapy and can be a gateway to the sphere of personalized medicine. On a more problematic side, it implies a less intense effect compared to single-target molecular therapies and a difficulty of elucidating the exact mechanisms of action, while also making the rational design of theirs for this type of medical application a challenge.

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Section: Introductionmentioning

confidence: 99%

Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: In search of the key particle property

et al. 2019

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“…CPP-ACP is not only available as a paste for home use but also in the form of varnish in combination with fluoride, chewing gum, mouth rinses, lozenges, dentifrices, spray, and energy drinks. The varnish containing CPP-ACP is shown to be more effective than the fluoride varnish to prevent WSL around orthodontic brackets [101][102][103].…”

Section: Increasing Tooth Resistancementioning

confidence: 95%

The Relationship between Orthodontic Treatment and Dental Caries

Metin-Gürsoy¹,

Uzuner²

2018

Dental Caries - Diagnosis, Prevention and Management

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Orthodontic treatment is the main treatment procedure to achieve a well-aligned dental arch and an esthetic smile. For this purpose, various types of removable or fixed orthodontic appliances are designed. However, each has their specific disadvantages. The most important one is that orthodontic appliances especially the brackets and the ligation mode create new retention areas in addition to blocking plaque-removing shear forces arising from fluid flow and masticatory loads with a resultant undesired effect of accumulation of dental plaque. Increased amount of dental plaque containing cariogenic bacteria is the main etiologic factor in decalcification of enamel during orthodontic treatment. This demineralization of the tooth surfaces results in appearance of white spots or even caries. However, in the literature, there are conflicting results in the relationship between orthodontic treatment and development of dental caries. Many preventive methods such as topical fluoride application, using bonding materials releasing fluoride, using mouth rinse with sodium fluoride, applying chlorhexidine, and so on were defined. The general comment of the authors is that supplying an adequate oral hygiene has the main role in prevention of demineralization-caries during orthodontic treatment. In the light of the previous studies' results, it can be concluded that professional application like a varnish can be provided for patients who have high caries incidence.

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“…Morgan et al in 2008 conducted 2 year in vivo study and resulted that CPP-ACP significantly slowed progression of enamel caries on proximal surfaces [27]. [28,29]. A portion of 5 gm of CPP-ACP delivered 148% more remineralization contrasted with 2 gm of CPP-ACP per liter of milk.…”

Section: Casein Phosphor Peptide -Amorphous Calcium Phosphate (Cpp-acp)mentioning

confidence: 99%

The Role of Remineralizing Agents Used in Dentistry: An Update Then and Now

Rather¹,

Kazi²,

Kazi³

2020

SJBR

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Among oral diseases dental caries is a highly prevalent multifactorial disease and has been a major public health problem for many centuries. Several remineralizing agents helps in remineralization to prevent disease progression, and to improve form and function of the teeth. Remineralization is the process of depositing calcium and phosphate ions into crystal voids in demineralized enamel, thus producing net mineral gain. The present article reviews about the various agents that enhance and promote remineralization of tooth structure and their implementation into clinical practice.

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Casein phosphopeptide-amorphous calcium phosphate in dentistry: An update

Cited by 33 publications

References 2 publications

Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: In search of the key particle property

Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: In search of the key particle property

The Relationship between Orthodontic Treatment and Dental Caries

The Role of Remineralizing Agents Used in Dentistry: An Update Then and Now

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