Casein phosphopeptide–amorphous calcium phosphate remineralization of primary teeth early enamel lesions

Zhou, Chunhua; Zhang, Dongliang; Bai, Yuxing; Li, Song

doi:10.1016/j.jdent.2013.11.005

Cited by 80 publications

(82 citation statements)

References 36 publications

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“…Although enamel is a hard and dense material, it possesses local differences in porosity and acid solubility; acids can penetrate deep into enamel and dissolve tooth minerals locally, rather than dissolving the enamel layer by layer (17) . Therefore, remineralization of early enamel lesions is of great value to protect other dental tissues.Moreover, it was found that dentin remineralization is more difficult than enamel remineralization due to the abundant presence of organic matrix in dentine (22) .…”

Section: Discussionmentioning

confidence: 99%

“…This pattern of demineralization might be due to the fact that the enamel surface is a homogenous, structureless and a prismatic (17)(18) , or as a result of collection of narrow porosities which might lead to the presence of wide erosion cavities. This agreed with several studies who found that enamel after demineralization appeared eroded and with a high degree of surface porosity showing a honeycomb-like structure (17) . This morphological aspect was reflected in the values of Ra which increase significantly from 88nm of intact enamel to about 178nm of demineralized enamel.…”

Section: Discussionmentioning

confidence: 99%

“…Any teeth with defects, erosions or micro-cracks on their enamel surfaces, or visible stains on the facial surfaces were excluded (17) .…”

Section: Methodsmentioning

confidence: 99%

“…Each tooth-half was fixed with superglue on the custom made acrylic block so that the buccal side of each was available, and assigned a serial number from 1 to 40. The labial surfaces were polished sub-sequentially starting from 600-grit abrasive paper discs up to 1200 grit under water irrigation to produce flat enamel surfaces (16)(17)(18)(19) . Enamel samples were divided equally into two groups according to the material used (A 1 ), (A 2 ) and further subdivided into four subgroups according to the number of applications (A 1 B 1 ), (A 1 B 2 ), (A 2 B 1 ) and (A 2 B 2 ).…”

Section: Methodsmentioning

confidence: 99%

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Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Any teeth with defects, erosions or micro-cracks on their enamel surfaces, or visible stains on the facial surfaces were excluded (17) .…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

2017

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“…4,5 Therefore, the synthetic CaP-based biomaterials (such as bone cements and porous ceramics) have been widely used in treatment of bone and tooth defects. [6][7][8] Electrospinning is a simple method of fabricating polymer/composite nanofibers and bioceramics which are widely used in drug delivery and tissue engineering. …”

Section: Introductionmentioning

confidence: 99%

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

Fu¹,

Zi²,

Xu³

et al. 2016

IJN

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Calcium phosphate-based biomaterials have been well studied in biomedical fields due to their outstanding chemical and biological properties which are similar to the inorganic constituents in bone tissue. In this study, amorphous calcium phosphate (ACP) nanoparticles were prepared by a precipitation method, and used for preparation of ACP-poly( d , l -lactic acid) (ACP-PLA) nanofibers and water-soluble drug-containing ACP-PLA nanofibers by electrospinning. Promoting the encapsulation efficiency of water-soluble drugs in electrospun hydrophobic polymer nanofibers is a common problem due to the incompatibility between the water-soluble drug molecules and hydrophobic polymers solution. Herein, we used a native biomolecule of lecithin as a biocompatible surfactant to overcome this problem, and successfully prepared water-soluble drug-containing ACP-PLA nanofibers. The lecithin and ACP nanoparticles played important roles in stabilizing water-soluble drug in the electrospinning composite solution. The electrospun drug-containing ACP-PLA nanofibers exhibited fast mineralization in simulated body fluid. The ACP nanoparticles played the key role of seeds in the process of mineralization. Furthermore, the drug-containing ACP-PLA nanofibers exhibited sustained drug release which simultaneously occurred with the in situ mineralization in simulated body fluid. The osteoblast-like (MG63) cells with spreading filopodia were well observed on the as-prepared nanofibrous mats after culturing for 24 hours, indicating a high cytocompatibility. Due to the high biocompatibility, sustained drug release, and fast mineralization, the as-prepared composite nanofibers may have potential applications in water-soluble drug loading and release for tissue engineering.

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Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion

Memarpour

Soltanimehr

Sattarahmady

2015

Microsc. Res. Tech.

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The aim of the study was to determine the efficacy of different products containing fluoride, calcium and phosphate for enamel remineralization in eroded primary teeth. A total of 90 sound primary canine teeth were randomly divided into 5 groups of 18 teeth each: 1) control (polished enamel), 2) 5% DuraShield sodium fluoride varnish, 3) 500 ppm fluoridated toothpaste, 4) casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) cream, and 5) Clinpro White varnish containing functionalized tri-calcium phosphate (fTCP). Enamel microhardness (EMH) was measured in all samples before and after demineralization and after 28 days of remineralization. Also 8 samples in groups 2 to 5 and four samples of sound and demineralized enamel were examined with atomic force microscopy (AFM). All data were analyzed with one-way ANOVA (p<0.05). Mean microhardness of demineralized enamel was significantly lower than in enamel at baseline (p<0.001). Remineralization significantly increased microharness in groups 2 to 5 compared to the control group (p<0.001). Percent EMH after remineralization with CPP-ACP was significantly higher than after fTCP (p=0.029), toothpaste (p< 0.001) or fluoride varnish (p<0.001); however, there was no significant difference between toothpaste and fluoride varnish (p=0.062). Microhardness increased more after fTCP treatment than after treatment with sodium fluoride varnish (p<0.001) or fluoridated toothpaste (p=0.045). AFM images showed that enamel roughness decreased most after treatment with fTCP, followed by CPP-ACP, toothpaste and fluoride varnish. The efficacy of CPP-ACP cream for remineralizing eroded enamel was greater than fluoride toothpaste, fluoride varnish or fTCP varnish.

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Casein phosphopeptide–amorphous calcium phosphate remineralization of primary teeth early enamel lesions

Cited by 80 publications

References 36 publications

Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

Remineralization of Early Carious Lesions using Biomimetic Selfassembling Peptides Versus Fluoride agent. (In vitro and In vivo study)

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion

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