Cases of Carcinoma of Thyroid following Iodine-131 Therapy for Hyperthyroidism

Gossage, A. A. R.; Neal, F. E.; Ross, C. M. D.; Talbot, C. H.; Blake, Glen M.; Munro, D. S.

doi:10.1159/000225782

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…From Doniach's work and the incidence of occult cancers it is not surprising that the patient developed a carcinoma for he had a persistent stimulus to the thyroid, albeit a thyroid stimulating immunoglobin rather than TSH, and he had been earlier treated with a small dose of 1311. Gossage et al 15 have reported a somewhat similar case who developed and died from an anaplastic carcinoma 23 years after 1311 therapy. Burke et al 16 also reported a 37 year old female who developed a follicular carcinoma 11 years after 1311 therapy, having been mildly hyperthyroid all the time.…”

Section: Discussionmentioning

confidence: 92%

Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves’ disease

Staffurth

Holl‐Allen²

1988

Postgraduate Medical Journal

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Summary:A 67 year old man presented with a well differentiated follicular carcinoma of the thyroid 17 years after he had been given radioactive iodine for Graves' disease. As this was insufficient to cure him he had continued to take propylthiouracil regularly. The tumour, which had completely replaced the thyroid, was apparently maintaining thyrotoxicosis. The implications of this management are discussed and it is concluded that antithyroid drugs should not be given on a long term basis after therapeutic radioiodine has been administered.

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Section: Discussionmentioning

confidence: 92%

Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves’ disease

Staffurth

Holl‐Allen²

1988

Postgraduate Medical Journal

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“…38 In addition to these cellular effects, it also induces some histological changes. 47 Although, the causeeffect relationship between low-dose RAI treatment and development of anaplastic thyroid cancer cannot be proven, it is obvious that followup including US examinations should continue for life long in patients who received RAI for hyperthyroidism. Histological examination might reveal multiple adenomatous nodules, follicular atrophy and fibrosclerosis, prominent oncocytic changes with nuclear atypia, and interstitial lymphocytic infiltrates and macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…46 The interval between RAI and diagnosis of anaplastic thyroid cancer is more than 10 years in nearly all cases, reaching to 23 years in some. 47 Although, the causeeffect relationship between low-dose RAI treatment and development of anaplastic thyroid cancer cannot be proven, it is obvious that followup including US examinations should continue for life long in patients who received RAI for hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ultrasonographical and cytological features of thyroid nodules in patients treated with radioactive iodine for hyperthyroidism

Bilginer¹,

Özdemır

Seyrek

et al. 2019

Diagnostic Cytopathology

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Background: In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago. Methods:Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine-needle aspiration biopsy (FNAB) were included in the study.Results: There were 27 patients (22 female and 5 male) with a mean age of 59.3 ± 13.5.The indication for RAI treatment was Graves in 5 (18.6%), toxic nodular or multinodular goiter in 16 (69.2%), and unknown in 6 (22.2%) patients. A total of 48 thyroid nodules were evaluated with FNAB and cytological diagnosis were benign in 24 (50.0%), nondiagnostic in 15 (31.2%), atypia of undetermined significance in 5 (10.4%), suspicous for malignancy in 2 (4.2%), and malignant in 2 (4.2%) nodules. Thyroidectomy was performed in 10 patients, 5 were benign (50.0%), and 5 (50.0%) were malignant histopathologically. Ultrasonography features of 31 cytologically/histopathologically benign and five cytologically/histopathologically malignant nodules were compared. Prevalence of isoechoic nodules was higher in benign nodules (P = .025). Macrocalcification was observed in 4 (80.0%) of malignant and 10 (32.3%) of benign nodules (P = .042). Conclusion:In patients with a history of RAI treatment for hyperthyroidism, thyroid nodules with suspicious ultrasonography features, particulary hypoechoic appearence and macrocalcification, should be evaluated with FNAB irrespective of the time elapsed after RAI treatment. K E Y W O R D Scytology, fine-needle aspiration biopsy, histopathology, hyperthyroidism, radioactive iodine

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“…This cancer was elicited 12-20 years after RAI 131 [26][27][28]. The Cooperative Thyrotoxicosis Therapy Follow-up Study concluded that thyroid cancer after radioactive iodine ablation developed in those people receiving lower rather than higher doses of RAI 131 therapy [29].…”

Section: Discussionmentioning

confidence: 99%

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Eyadeh

Al-Sarihin

Etewi

et al. 2017

Endokrynologia Polska

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Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI 131 treatment for hyperthyroidism and to report the index cases' characteristics and management Material and methods: A cohort of 264 patients who received RAI 131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014) by physical exam, radiological evaluation and serial thyroid function tests. Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer was 1.136% of cases who received RAI 131 . The relative risk was 378.79 (95% CI: 76.8 < RR < 1868.23). The P value was < 0.0000004 and the SMR is 1.99/1000. Conclusions: The prevalence of thyroid cancer was 1.136% in the cohort of patients treated with RAI

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Cases of Carcinoma of Thyroid following Iodine-131 Therapy for Hyperthyroidism

Abstract: 2 cases of anaplastic thyroid cancer are described which developed after treatment of hyperthyroidism with iodine-131.

Cited by 12 publications

References 15 publications

Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves’ disease

Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves’ disease

Evaluation of ultrasonographical and cytological features of thyroid nodules in patients treated with radioactive iodine for hyperthyroidism

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

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