2003
DOI: 10.1038/sj.cdd.4401364
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Caspase-12: an overview

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Cited by 121 publications
(99 citation statements)
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References 33 publications
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“…In our system, we cannot rule out the possibility that this anti-caspase 12 antibody may cross-react with another as yet unidentified caspase, however, the activation of this caspase is clearly restricted to ER stress-initiated apoptosis. Several mechanisms of caspase 12 activation have been identified, and would seem to be cell type specific (37). The present study shows that bortezomib-mediated activation of caspase 12 may be modulated by caspase 8, but is dependent on mitochondrial Ca 2+ disregulation.…”
Section: Discussionmentioning
confidence: 64%
“…In our system, we cannot rule out the possibility that this anti-caspase 12 antibody may cross-react with another as yet unidentified caspase, however, the activation of this caspase is clearly restricted to ER stress-initiated apoptosis. Several mechanisms of caspase 12 activation have been identified, and would seem to be cell type specific (37). The present study shows that bortezomib-mediated activation of caspase 12 may be modulated by caspase 8, but is dependent on mitochondrial Ca 2+ disregulation.…”
Section: Discussionmentioning
confidence: 64%
“…The HIP rat is transgenic for human IAPP, expressing high levels of human IAPP. Activated caspase-12, a marker of ER stress in rodents (22,23), was much more abundant in HIP than in wild-type islets ( Fig. 2B and Table 2).…”
Section: Fig 3 Er Stress Marker Gadd153/chop Is Induced In the Pancmentioning
confidence: 99%
“…ICE cleaves pro-IL-1b to yield active cytokine; however, it does so in the absence of apoptosis induction (Black et al 1989a;Kostura et al 1989). Based on multiple reports revealing the functional roles and activation mechanisms of caspases, caspases are now divided into three functional groups: apoptosis induction (caspase-2, -3, -6, -7, -8, -9, and -10) (Guo et al 2002;Kischkel et al 2001;Parrish et al 2013), inflammatory responses (caspase-1, -4, -5, and -12) (Bian et al 2011;Black et al 1989a;Kostura et al 1989;Lamkanfi et al 2004;Sollberger et al 2012), and differentiation (caspase-14) (Denecker et al 2008) (Fig. 1).…”
Section: Introductionmentioning
confidence: 99%