Caspase-3 mediated programmed cell death by a gold-stabilised peptide carbene

Gupta, Astha; Nigam, Shivansh; Avasthi, Ilesha; Sharma, Bikramjit; Ateeq, Bushra; Verma, Sandeep

doi:10.1016/j.bmcl.2019.126672

Cited by 5 publications

(9 citation statements)

References 36 publications

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“…An actin depolymerising effect of metal‐based candidate molecules was observed in some studies, including ruthenium(II) cyclopentadienyl complexes with bipyridine ligands ( A14 ) [83] and a gold(I) thiazolylalanine bis‐NHC complex [74] . Actin depolymerisation was generally followed by apoptosis‐induction.…”

Section: Effects Of Metal‐based Candidate Drugs On Actinmentioning

confidence: 96%

“…It is worth mentioning that there are also reports of metal‐based candidate molecules that did not show any impact on the actin cytoskeleton. Among those were rhenium(I) tricarbonyl phenanthroline complexes, [87] gold porphyrin compounds tethered to organotin(IV) entities [88] and a mercury(I) thiazolylalanine bis‐NHC complex whose isostructural gold analogue actually destabilises actin [74] …”

Section: Effects Of Metal‐based Candidate Drugs On Actinmentioning

confidence: 99%

“…Destabilising effects of metal-based candidate molecules on actin were more frequently observed and range from inhibition of polymerisation, [19b] to disruption [52,74] and even degradation. [75] F-actin remodelling was associated with platinum resistance.…”

Section: Destabilising Effects On Actinmentioning

confidence: 99%

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Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

et al. 2023

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During recent years, accumulating evidence suggested that metal‐based candidate drugs are promising modulators of cytoskeletal and cytoskeleton‐associated proteins. This was substantiated by the identification and validation of actin, vimentin and plectin as targets of distinct ruthenium(II)‐ and platinum(II)‐based modulators. Despite this, structural information about molecular interaction is scarcely available. Here, we compile the scattered reports about metal‐based candidate molecules that influence the cytoskeleton, its associated proteins and explore their potential to interfere in cancer‐related processes, including proliferation, invasion and the epithelial‐to‐mesenchymal transition. Advances in this field depend crucially on determining binding sites and on gaining comprehensive insight into molecular drug‐target interactions. These are key steps towards establishing yet elusive structure‐activity relationships.

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Section: Effects Of Metal‐based Candidate Drugs On Actinmentioning

confidence: 96%

Section: Effects Of Metal‐based Candidate Drugs On Actinmentioning

confidence: 99%

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Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

et al. 2023

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“…Spirooxindole‐pyrrolidine heterocyclic hybrid, 3‐(4‐Methylphenyl)‐4‐nitro‐5‐(4‐hydroxybenzyl) spiro [trifluoromethoxyindoline‐3′.2‐pyrrolidin]‐2′‐one (4j) was reported to show significant cytotoxic effect in A549 cells with IC50 values 38.66 ± 1.50 and 29.60 ± 6.20 µM for 24 and 48 h, respectively 123 . Novel N‐heterocyclic gold‐stabilized carbene complex showed significant apoptotic activity against the MCF7 breast cancer cell line through increased activation of caspase‐3 levels 124 . Kumar, Raju Suresh, et al synthesized and tested a small library of cage‐like heterocyclic hybrids encompassing pyrroloisoquinolines, pyridinone, and acenaphthene structural moieties, where compound 1 g showed dose‐dependent cytotoxicity with IC50 values of 12.14 ± 1.53 and 10.68 ± 0.68 µM against HCT116 and JURKAT cell line, respectively 130 .…”

Section: Role Of Phytochemicals As Caspase Inducers: Natural Semisynt...mentioning

confidence: 99%

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Allani,

Akhilesh,

Tiwari

2024

Cell Biochemistry & Function

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Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse range of natural, synthetic, and semisynthetic compounds and their derivatives have been investigated for their caspase‐mediated apoptosis‐induced anticancer activities. The review aims to compile the preclinical evidence and highlight the critical mechanistic pathways related to caspase‐induced cell apoptosis in cancer treatment. The focus is placed on the key components of the mechanisms, including their chemical nature, and specific attention is given to phytochemicals derived from natural sources and synthetic and semisynthetic compounds. 180+ compounds from the past two decades with potential as anticancer agents are discussed in this review article. By summarizing the current knowledge and advancements in this field, this review provides a comprehensive overview of potential therapeutic strategies targeting apoptosis in cancer cells. The findings presented herein contribute to the ongoing efforts to combat cancer and stimulate further research into the development of effective and targeted anticancer therapies.

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“…There are also several other publications reporting caspase-3 protein expression in MCF-7 cells. , There are several possibilities that could account for such discrepant findings. First, inappropriate antibodies might cross-react with other caspase-3 unrelated proteins .…”

mentioning

confidence: 97%

Comment on: “Codelivery of Gemcitabine and MUC1 Inhibitor Using PEG-PCL Nanoparticles for Breast Cancer Therapy”

Tian

2022

Mol. Pharmaceutics

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Caspase-3 mediated programmed cell death by a gold-stabilised peptide carbene

Cited by 5 publications

References 36 publications

Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

Exploring the Potential of Metal‐Based Candidate Drugs as Modulators of the Cytoskeleton

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Comment on: “Codelivery of Gemcitabine and MUC1 Inhibitor Using PEG-PCL Nanoparticles for Breast Cancer Therapy”

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