Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised and investigated for their in vivo anti-inflammatory, analgesic and ulcerogenic activities. Molecular docking showed an excellent binding interaction of the synthesised compounds with the receptors, with 17c showing the highest binding energy (-12.50 kcal/mol). Compounds 17c and 17i inhibited carrageenan-induced rat paw oedema at 72, 76, and 80% and 64, 73, and 78% at 1 h, 2 h, and 3 h, respectively. In the analgesic activity experiment, compounds 17c, 17 g, and 17i had ED 50 (mM/kg) of 96, 127, and 84 after 0.5 h; 102, 134, and 72 after 1 h and 89, 156, and 69 mM/kg after 2 h, respectively, which were comparable with 156, 72, and 70 mM/kg for celecoxib. The ulcerogenic index of the most active derivatives 17c and 17i were 0.82 and 0.89, respectively, comparable to 0.92 for celecoxib. The physicochemical studies of the new derivatives showed that they will not have oral bioavailability problems. ARTICLE HISTORY

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Chromium(VI) has been found to be one of the toxic metals present in water obtained from industrial effluents. This study deals with the removal of Cr(VI) using used green tea leaves, which is a waste material. The sorption of Cr(VI) was carried out by using a batch method, and its concentration was determined using an ultraviolet visible spectrophotometer at 540 nm. Parameters such as pH, mass of adsorbate, concentration of adsorbent, time of contact, and temperature were optimized. It was observed that, under optimum conditions, the percentage efficiency of removal of Cr(VI) was up to 99%. Adsorption studies were carried out using Langmuir and Freundlich adsorption isotherms. The values of ΔG, ΔH, and ΔS were also calculated, which showed that the process is spontaneous and the extent of adsorption decreases with the increase in temperature. The kinetic studies were carried out, and it was found that the reactions followed pseudo-second-order kinetics. This technique can be used for the removal of Cr(VI) from water obtained from industries, which have chromium as one of the main pollutants in their effluents.

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