Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis

Wang, Limei; Yan, Haijing; Chen, Xiaomeng; Lee, Jieun; Sun, Jiao; Liu, Guibo; Yang, Hua; Lu, Danli; Liu, Wenting; Che, Chengye

doi:10.1016/j.intimp.2022.109275

Cited by 5 publications

(3 citation statements)

References 50 publications

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“…Although we did not investigate cell recruitment in this study, we hypothesize that innate cells recruitment to the site of infection may be impaired by the absence of pyroptosis in caspase-8 deficient animals, which could in part explain the increased bacterial load observed in these animals. Recently, caspase-8 was involved in Aspergillus fumigatus keratitis being critical in the recruitment of inflammatory cells and the clearance of the fungus ( Wang et al, 2022 ). In summary, we suggest that caspase-8 plays an important role in cell death induced during B.abortus infection, contributing to inflammation and infection control in mice.…”

Section: Discussionmentioning

confidence: 99%

Caspase-8 but not caspase-7 influences inflammasome activation to act in control of Brucella abortus infection

et al. 2022

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Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others. Brucella abortus is a gram-negative bacterium that causes a zoonotic disease termed brucellosis. The innate immune response against this pathogen involves activation of inflammasome components and induction of pyroptosis. However, no studies so far have revealed the role of caspase-7 or caspase-8 during this bacterial infection. Herein, we demonstrate that caspase-7 is dispensable for caspase-1 processing, IL-1β secretion and cell death in macrophages. Additionally, caspase-7 deficient animals control B. abortus infection as well as the wild type mice. Furthermore, we addressed the role of caspase-8 in inflammasome activation and pyroptosis during this bacterial infection. Macrophages deficient in caspase-8 secreted reduced amounts of IL-1β that parallels with diminished caspase-1 activity when compared to wild type cells. Additionally, caspase-8 KO macrophages showed reduced LDH release when compared to wild type, suggesting that caspase-8 may play an important role in pyroptosis in response to B. abortus. Finally, caspase-8 KO animals were more susceptible to Brucella infection when compared to wild type mice. Overall, this study contributes to a better understanding of the involvement of caspase-7 and caspase-8 in innate immunity against B. abortus infection.

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Section: Discussionmentioning

confidence: 99%

Caspase-8 but not caspase-7 influences inflammasome activation to act in control of Brucella abortus infection

et al. 2022

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“…[161] Nanomaterials carrying therapeutic bacteria offer attractive prospects for clinical applications as they sidestep the rapid elimination of bacteria in vivo and reduce the risk of systemic inflammatory reactions. [162,163] To this end, Liu et al developed an immunotherapy system (Lmo@RBCs) that used Listeria monocytogenes (Lmo) and red blood cell (RBC) membrane coating to trigger pyroptosis via NADPH oxidase-mediated ROS in the caspase-8/GSDMC pathway, thereby promoting an anti-tumor immune response (Figure 9A). [164] Specifically, the RBC membrane on the Lmo@RBCs surface fused with the tumor cell membrane to release Lmo, which under the protection of TME, grew and proliferated within tumor cells and promoted massive ROS production by activating NADPH oxidase.…”

Section: Pyroptosis Activation Via the Caspase-8/gsdmc-mediated Pathw...mentioning

confidence: 99%

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

Wang

2023

Adv Healthcare Materials

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Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of programmed cell death. Its occurrence is mediated by the gasdermin protein, leading to characteristic outcomes including cell swelling, membrane perforation, and release of cell contents. Research underscores the role of pyroptosis in the etiology and progression of many diseases, making it a focus of research intervention as scientists explore ways to regulate pyroptosis pathways in disease management. Despite numerous reviews detailing the relationship between pyroptosis and disease mechanisms, few delve into recent advancements in nanomaterials as a mechanism for modulating the pyroptosis pathway to mitigate disease effects. Therefore, there is an urgent need to fill this gap and elucidate the path for the use of this promising technology in the field of disease treatment. This review article delves into recent developments in nanomaterials for disease management through pyroptosis modulation, details the mechanisms by which drugs interact with pyroptosis pathways, and highlights the promise that nanomaterial research holds in driving forward disease treatment.

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“…However, a recent study by Khanova et al showed that pyroptosis in liver inflammation is induced by the noncanonical caspase-11 pathway, rather than caspase-1, and is a key mechanism driving the progression of ASH to AH (Khanova et al, 2018). Pyroptosis is also a vital feature of aseptic liver diseases, such as high fat diet-induced liver damage, polystyrene microplastics-induced liver injury, acetaminophen-induced liver damage, hepatic ischemia-reperfusion damage and cholestatic liver diseases (Zhang et al, 2021c;Lu et al, 2021;Wang et al, 2022b;Han et al, 2022;Mu et al, 2022). Taken together, identification of novel pyroptosis-related targets can provide new insights for the treatment of the above diseases.…”

Section: Pyroptosis In Liver Diseasesmentioning

confidence: 99%

The role of pyroptosis in inflammatory diseases

Chai

Liu

Shui

et al. 2023

Front. Cell Dev. Biol.

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Programmed cell death has crucial roles in the physiological maturation of an organism, the maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed cell death which has recently received much attention, is closely related to inflammation and occurs via canonical, non-canonical, caspase-3-dependent, and unclassified pathways. The pore-forming gasdermin proteins mediate pyroptosis by promoting cell lysis, contributing to the outflow of large amounts of inflammatory cytokines and cellular contents. Although the inflammatory response is critical for the body’s defense against pathogens, uncontrolled inflammation can cause tissue damage and is a vital factor in the occurrence and progression of various diseases. In this review, we briefly summarize the major signaling pathways of pyroptosis and discuss current research on the pathological function of pyroptosis in autoinflammatory diseases and sterile inflammatory diseases.

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Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis

Cited by 5 publications

References 50 publications

Caspase-8 but not caspase-7 influences inflammasome activation to act in control of Brucella abortus infection

Caspase-8 but not caspase-7 influences inflammasome activation to act in control of Brucella abortus infection

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

The role of pyroptosis in inflammatory diseases

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