Caspase Inhibitors, but not c-Jun NH2-Terminal Kinase Inhibitor Treatment, Prevent Cisplatin-Induced Hearing Loss

Wang, Jing; Ladrech, Sabine; Pujol, Rémy; Brabet, Philippe; Water, Thomas R. Van De; Puel, Jean–Luc

doi:10.1158/0008-5472.can-04-1581

Cited by 191 publications

(181 citation statements)

References 28 publications

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“…They also complement the many other recent studies that have documented signal transduction pathways leading to hair death due to a variety of stressors, including aminoglycosides (e.g., Pirvola et al 2000;Bodmer et al 2002a), cisplatin (e.g., Zhang et al 2003;Wang et al 2004), and noise exposure (e.g., Harris et al 2005;Lang et al 2006).…”

Section: Figsupporting

confidence: 67%

A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti

Chung

Pak²,

Lin³

et al. 2006

JARO

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Section: Figsupporting

confidence: 67%

A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti

Chung

Pak²,

Lin³

et al. 2006

JARO

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“…While many drugs have been demonstrated to successfully protect hair cells against damage (e.g., antioxidants, caspase inhibitors, Stat-1, etc. ; Matsui et al 2002;Wang et al 2003Wang et al , 2004Sha et al 2006;Campbell et al 2007;Schmitt et al 2009), there is currently no FDA-approved drug used for the prevention of hearing loss. Aspirin was demonstrated to protect against aminoglycoside-induced hair cell death (Sha et al 2006), but required high daily doses (3 g/day).…”

Section: Introductionmentioning

confidence: 99%

Quinoline Ring Derivatives Protect Against Aminoglycoside-Induced Hair Cell Death in the Zebrafish Lateral Line

Keating

et al. 2012

JARO

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We have previously published results from a screen of 1,040 FDA-approved drugs and bioactives (NINDS Custom Collection) for drugs that protect against neomycin-induced hair cell death (Ou et al., J Assoc Res Otolaryngol 10:191-203, 2009). Further evaluation of this drug library identified eight protective drugs that shared a common quinoline scaffold. These drugs were tested further in terms of their protection against other aminoglycosides, as well as their effect on aminoglycoside uptake. All of the eight quinolines that protected against neomycin were found to protect against shortand long-term gentamicin damage protocols. We then tested the structurally related compounds quinoline, isoquinoline, naphthalene, and indole for protective effects. Of these compounds, indole demonstrated a small but significant amount of protection against neomycin, while quinoline and isoquinoline partially protected against long-term gentamicin damage. We examined whether the protective activity of this group of compounds was related to known targets of the quinoline derivatives. The protective effects did not seem linked to either the cholinergic or histaminergic pathways that are regulated by some members of the quinoline family. However, all eight protective drugs were found to reduce the uptake of aminoglycosides into hair cells. Subsequent experiments suggest that reduction of uptake is the primary mechanism of protection among the quinoline drugs.

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“…A subset of cell signaling proteins appear to be involved in cisplatin ototoxicity, including the tumor suppressor p53 (Devarajan et al, 2002;Zhang et al, 2003), the MAP kinase protein ERK (So et al, 2007), caspases, and cytochrome c (Devarajan et al, 2002;Kaushal et al, 2001;Liu et al, 1998;Wang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK

et al. 2010

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Caspase Inhibitors, but not c-Jun NH2-Terminal Kinase Inhibitor Treatment, Prevent Cisplatin-Induced Hearing Loss

Cited by 191 publications

References 28 publications

A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti

A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti

Quinoline Ring Derivatives Protect Against Aminoglycoside-Induced Hair Cell Death in the Zebrafish Lateral Line

Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK

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