2014
DOI: 10.1128/aac.03117-14
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Caspofungin at Catheter Lock Concentrations Eradicates Mature Biofilms of Candida lusitaniae and Candida guilliermondii

Abstract: The antibiofilm activities of caspofungin, anidulafungin, micafungin, and liposomal amphotericin B were studied against Candida lusitaniae, Candida guilliermondii, and a Candida albicans control strain. While anidulafungin and micafungin (0.007 to 2,048 mg/liter) showed reduced activity against biofilms of both test species, caspofungin displayed concentration-dependent antibiofilm activity, reaching complete and persistent eradication at concentrations achievable during lock therapy (512 to 2,048 mg/liter, P … Show more

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Cited by 17 publications
(23 citation statements)
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“…But higher bioactivity due to smaller nano-sized particles at lower concentration of compounds has already been reported in the literature. [45][46][47] In our present investigation, the size distribution study reveals that with dilution up to 30 mg mL À1 concentration, smallest nano-sized particles were formed. And likewise due to free nanoparticles, the 30 mg mL À1 concentration exhibited increased antibiolm activity.…”
mentioning
confidence: 96%
“…But higher bioactivity due to smaller nano-sized particles at lower concentration of compounds has already been reported in the literature. [45][46][47] In our present investigation, the size distribution study reveals that with dilution up to 30 mg mL À1 concentration, smallest nano-sized particles were formed. And likewise due to free nanoparticles, the 30 mg mL À1 concentration exhibited increased antibiolm activity.…”
mentioning
confidence: 96%
“…Biofilm-associated Candida show uniform resistance to a wide spectrum of the currently available conventional antifungal agents, which implies that antimicrobial drugs that specifically target biofilm-associated infections are needed. It has been shown that some antifungals were able to cause damage to the biofilm structures of Candida species [ 13 ]. However, these antifungals should be used in high concentrations and species-specific differences in the susceptibilities of the biofilms formation have been observed [ 8 , 10 ].…”
Section: Resultsmentioning
confidence: 99%
“…Currently, a limited number of antifungals such as amphotericin B, fluconazole, itraconazole, and voriconazole are available. Other antifungal agents such as posaconazole, ravuconazole, caspofungin, and micafungin show promising results [ 2 , 12 , 13 ]. However, the application of azole derivative agents such as itraconazole may result in various side effects such as cardiac failure, mitochondrial dysfunction, or cardiomyopathy [ 14 ].…”
Section: Introductionmentioning
confidence: 99%
“… 2008 ; Simitsopoulou et al. 2014 ). It was also reported that the presence of many molecules together may mask the activity of active compounds (Harrison et al.…”
Section: Discussionmentioning
confidence: 99%