Castelman's disease of the neck: a case report and literature review

Abstract

Castleman’s disease is a rare pathology, poorly understood. It is considered as a lymphoproliferative disorder, described for the first time in 1954, which may be confused with other causes of lymphadenopathy. We report in this paper the case of a young women presenting with left latero-cervical lymphadenopathy. All the investigations were negative except a large high-vascularized level II cervical lymphadenopathy. We performed a cervicotomy. The extemporaneous histological exam was non-contributive. We decided to perform a complete level II and III left cervical lymphadenectomy. The diagnosis of unicentric Castleman's disease was confirmed based on the final histological study of the specimen, and the absence of other cervical and extra-cervical lymphadenopathy. The patient is free of recurrence at the time of reporting this article.

Castleman’s disease: A report of two cases at a tertiary hospital in Northern Tanzania

“…The most prevalent clinical form is hyaline-vascular types; 7 90% of instances show follicular hyperplasia, regressed germinal centers, and vascular proliferation, whereas plasma cell types show large lymphoreticular nodules, Russell bodies, and hyaline blood arteries, and mixed types show characteristics of both HV types and plasma variants. 7,8 As it was in case 1, HV-CD usually presents as a large mass involving a lymph node (or group of lymph nodes). The hyaline variant represents 80%-90% of all cases of localized of CD.…”

“…Moreover, patients with MCD have a higher risk of coexistent chronic infections and can be associated with Kaposi's sarcoma, with the latter much more common in HIV-positive patients. [6][7][8] Patients with MCD subsequently may develop lymphomas. 9 Furthermore, anemia, hypoalbuminemia, cytopenias, and elevated inflammatory markers are common.…”

“…The most prevalent clinical form is hyaline-vascular types; 7 90% of instances show follicular hyperplasia, regressed germinal centers, and vascular proliferation, whereas plasma cell types show large lymphoreticular nodules, Russell bodies, and hyaline blood arteries, and mixed types show characteristics of both HV types and plasma variants. 7,8…”

Retroperitonealna lokalizacija Castelmanove bolesti kod pedijatrijskog pacijenta

“…Primjenjuje se kombinirana terapija koja uključuje primjenu kortikosteroida, imunosupresivnih lijekova, kemoterapije, radioterapije te kiruršku resekciju ako je moguća. Protiv sistemskih simptoma pozitivan učinak pokazala su protutijela protiv IL-6, a u zadnje vrijeme se sve više koriste i antivirusni lijekovi [13][14][15] .…”