Casting a Wide Net While Building a Safety Net: Addressing Disparities in Genetic Testing for Hereditary Cancer

Oncologic anthropology: Global variations in breast cancer risk, biology, and outcome

“…[43][44][45][46][47][48][49][50][51][52][53][54] Disparities in genetic testing have been well-documented in the United States, with disproportionately low rates among African Americans, and this has resulted in higher frequencies of Variants of Uncertain Significance detected in this population subset. [55][56][57][58][59][60][61] This clinical care disparity is alarming because the majority of BRCA1 mutation-associated breast cancers are TNBC, and African ancestry is associated with higher TNBC risk. It also has clinical relevance, because pathogenic BRCA mutations (but not VUSs) influence eligibility for PARP inhibitor therapy.…”