Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides

Cengiz, Fatma Pelin; Beyaztaş, Serap; Gökçe, Başak; Arslan, Oktay; Guler, Ozen Ozensoy

doi:10.3109/14756366.2014.908292

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…Overexpression of heat shock protein 90 (Hsp90) is common in various types of cancer, including cutaneous cancers 127–130 , as well as in chronic skin defects such as inflammation and burns 131–134 . Carbonic anhydrase II elevation has been reported in mycosis fungoides 135 , in adenomas, in glandular tumours (sweat, sebaceous, and major salivary glands), and in various tumours of the skin 136–139 . Cytochrome P450 enzyme systems are involved in drug biotransformation, and as such, are especially noteworthy for their involvement in numerous deleterious drug–drug interactions 140 , 141 .…”

Section: Resultsmentioning

confidence: 99%

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Boateng,

Roy,

Torrey

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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Twenty-five azole compounds ( P1 – P25 ) were synthesised using regioselective base-metal catalysed and microwave-assisted approaches, fully characterised by high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), and infrared spectra (IR) analyses, and evaluated for anticancer, anti-tyrosinase, and anti-oxidant activities in silico and in vitro . P25 exhibited potent anticancer activity against cells of four skin cancer (SC) lines, with selectivity for melanoma (A375, SK-Mel-28) or non-melanoma (A431, SCC-12) SC cells over non-cancerous HaCaT-keratinocytes. Clonogenic, scratch-wound, and immunoblotting assay data were consistent with anti-proliferative results, expression profiling therewith implicating intrinsic and extrinsic apoptosis activation. In a mushroom tyrosinase inhibition assay, P14 was most potent among the compounds (half-maximal inhibitory concentration where 50% of cells are dead, IC 50 15.9 μM), with activity greater than arbutin and kojic acid. Also, P6 exhibited noteworthy free radical-scavenging activity. Furthermore, in silico docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET) simulations predicted prominent-phenotypic actives to engage diverse cancer/hyperpigmentation-related targets with relatively high affinities. Altogether, promising early-stage hits were identified – some with multiple activities – warranting further hit-to-lead optimisation chemistry with further biological evaluations, towards identifying new skin-cancer and skin-pigmentation renormalising agents.

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Section: Resultsmentioning

confidence: 99%

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Boateng,

Roy,

Torrey

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…by measuring a decrease in absorbance at 240 nm, at 25 °C. The results were expressed as units per litre (U/L) 33 .…”

Section: Methodsmentioning

confidence: 99%

“…Suitable control was run simultaneously. Roussos 37 defined 1 U of activity as change in absorbance at 290 nm in 1 min by 1 ml enzyme preparation 33 .…”

Section: Methodsmentioning

confidence: 99%

Do CO₂and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients

Mutlu

Korkmaz

Simsek

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

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Head and neck cancer (HNC) is one of the most common malignancies in the world. HNC is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands. According to this section of the body parts; induction of cancer can be associated with CO2 and oxidative stress. The aim of this study is to assess the activities of carbonic anhydrase (CA), catalase (CAT), paraoxonase1 (PON1), and xanthine oxidase (XO) activities in 89 HNC patients and 115 healthy volunteers. Paraoxonase1 activity was found lower in HNC cancer patients. There is no statistically significant difference between patients and controls for catalase, carbonic anhydrase, and xanthine oxidase enzyme levels. According to this results, paraoxonase1 levels could be a candidate as an oxidative marker in HNC patients, but further studies are needed to investigate the other type of cancer related PON1 and the other enzyme levels.

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“…22 CAT aktivite seviyelerindeki değişiklikler oksidatif stres ve birçok spesifik hastalık ile ilişkilidir. 23…”

Section: Introductionunclassified

Gebe Bireylerde Sigaranın Kan Metabolik Enzim Aktiviteleri Üzerine Etkilerinin İncelenmesi

Şentürk,

Aslan,

Varol

et al. 2024

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

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Gebelik süreci hem biyokimyasal hem de fizyolojik olarak anne adayında birçok değişikliğe sebep olan bir süreçtir. Biyokimyasal değişimin en kolay gözlendiği ve yorumlandığı parametrelerden bir tanesi enzimatik değişimlerdir. Bu çalışmada, Ağrı’da gebe ve gebe olmayan iki grup kadından kan örnekleri alındı. Bu gruplar sigara içme durumlarına göre ikişer gruba ayrılarak bazı metabolik enzim seviyeleri kıyaslanmıştır. Bu kapsamda kan serum karbonik anhidraz (CA), eritrosit CA, kan serum katalaz (CAT), eritrosit CAT, kan serum asetilkolinesteraz (AChE) ve eritrosit AChE enzim düzeylerinin gebelerde ve gebe olmayanlarda karşılaştırılması amacıyla yapılmıştır. Çalışmamız, Ağrı il merkezinde yaşayan 35 gebe ve 54 gebe olmayan bireyden oluşmaktadır. Çalışmamıza katılan bireylerden kişisel bilgi formları yüz yüze görüşme ile doldurularak toplandı. Katılmayı kabul eden bireylerden 2 cc kan numunesi alındı. Kan örnekleri santrifüjlenerek serum ve kan hücreleri birbirinden ayrıldı. Elde edilen sonuçlar, GraphPad Prism 9 programı ile istatistiksel analizleri yapıldı. Yaptığımız bu araştırmada katılımcıların yaş ortalamaları gebe bireylerde 25, gebe olmayanlarda ise 22 olduğu belirlendi. Gebelerin %83’ünün sigara içmediği ve %96’sının ise kronik hastalığının olmadığı tespit edildi. Çalışmaya katılan gebe olmayan bireylerin %6,31’inin ise sigara kullandığı belirlendi. Elde edilen verilere göre sigara içen bayanların üç enzim için de hem serum hem de sitoplazma sonuçları daha düşük çıkmıştır. Gebelik durumunda ise sitoplazma AChE seviyeleri hariç bütün değerler azalmıştır.

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Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides

Cited by 5 publications

References 26 publications

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Do CO₂and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients

Gebe Bireylerde Sigaranın Kan Metabolik Enzim Aktiviteleri Üzerine Etkilerinin İncelenmesi

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Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides

Cited by 5 publications

References 26 publications

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Do CO2and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients

Gebe Bireylerde Sigaranın Kan Metabolik Enzim Aktiviteleri Üzerine Etkilerinin İncelenmesi

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Do CO₂and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients