Catalase reverses tumorigenicity in a malignant cell line by an epidermal growth factor receptor pathway

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

“…Consistent with recently performed genetic target validation studies that demonstrate the significant tumor suppressive effects of overexpression of cellular antioxidant enzymes including catalase and SOD (108,371), sacrificial and catalytic antioxidants may display potent anticancer activity in cellular systems and xenograft models. Pro-and antioxidant pharmacodynamic effects observed with small molecule SOD mimetics will be discussed in the context of anticancer intervention targeting the SOD system (Section III.A.2).…”

Anticancer Mechanism of Sulfur-Containing Compounds

“…As a consequence, the large amounts of ROS produced in some cancer cells could be necessary to mediate signaling events that lead to activation of redox-sensitive transcription factors and responsive genes involved in cancer cell growth, proliferation, and survival. Then, increasing ROS scavenging, thereby dampening signaling and depressing tumor growth, might be an attractive therapeutic strategy, which is supported by an increasing number of studies [55]. In the opposite direction, additional amounts of ROS above a certain threshold may be toxic for cancer cells and cause cell-cycle arrest and/or apoptosis [56].…”

Squamous Cell Carcinoma of the Skin: Current Strategies for Treatment and Prevention

“…One of the primary enzymatic antioxidant defenses that metabolize ROS within the cell is catalase [78]. The importance of catalase in the breakdown of ROS has been demonstrated using malignant mouse keratinocytes [79].…”

“…The importance of catalase in the breakdown of ROS has been demonstrated using malignant mouse keratinocytes [79]. In these malignant cells, overexpression of catalase can inhibit ROS and concomitantly establish a functional role for decreased catalase levels in augmenting the malignant phenotype [78,[80][81][82]. The overexpression of catalase also reduces UVB-induced apoptosis in normal human keratinocytes preventing DNA damage induced by increases in ROS [83,84].…”