Catalytic activity of immobilized metalloporphyrins prepared by synchronously synthesizing and immobilizing porphyrins on polymeric microspheres

Abstract

Trisomy 18 is a chromosomal syndrome characterized by a broad clinical picture, as well as a very reserved prognosis. The aim of our study was to verify the clinical characteristics and survival of patients diagnosed in a referral hospital in southern Brazil. Our sample consisted of 31 patients, 22 were female (71%), ages ranging from 1 to 1,395 days (median 14 days). The majority had a single cell lineage with full trisomy of chromosome 18 (94%). Concerning pregnancy complications, pre‐eclampsia was the main abnormality described (17%). Fetal ultrasound was performed in 23 cases, and the most frequent abnormalities were polyhydramnios (41%) and intrauterine growth retardation (27%). There were no reports of prenatal identification of the syndrome. Most patients were born by cesarean due to pregnancy and fetal complications and about half of the cases were premature. Congenital heart defects represented the main major malformation observed (94%). Thirty patients (97%) progressed to death (survival ranged from 2 to 780 days, and 87% died within the first 6 months of life). Trisomy 18 is a serious chromosomal disorder with limited survival. Abnormalities of pregnancy appear to be frequent, which can lead to complications for both fetus and mother. The prenatal identification of these patients in our country is still inadequate, resulting in important implications for genetic counseling and management of these patients and their families. And this makes the possibility of interruption of pregnancy, regardless of ethical factors involved, an unlikely option. © 2011 Wiley‐Liss, Inc.

A zinc sulfide-supported iron tetrakis (4-carboxyl phenyl) porphyrin catalyst for aerobic oxidation of cyclohexane

“…This microenvironment not only facilitates catalytic action but also effectively protects metalloporphyrins from dimer formation and destruction, thereby resulting in high catalytic activity. 16 Fig. 5D illustrates changes in the selectivity and yield of cyclohexanone and cyclohexanol, cyclohexane conversion, and TON under an optimal temperature of 160 C and pressure of 0.8 MPa catalyzed by Fe TCPP/ZnS.…”

“…Many supports can provide a suitable micro-environment for various reactions and site isolation of metalloporphyrins, reduce the formation of catalytically inactive m-oxo porphyrin dimers, and increase the stability of porphyrins toward the oxidant. 9 To improve the catalytic performance of the metalloporphyrins, immobilization of metalloporphyrins on chitosan, 10 organosilicon, 11 boehmite, 9,12 halloysite, 13 zinc hydroxide nitrate, 14 ferroferric oxide, 15 polymeric microspheres, 16,17 micro and mesoporous supports, 18 porous metal-organic frameworks, 19 and some other supports [20][21][22][23] has been investigated.…”

Zirconium (IV) porphyrin graphene oxide: a new and efficient catalyst for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones

“…Also, supports provide a suitable surface for doing organic reactions. Various supports have been reported for immobilization of metalloporphyrins like chitosan, organosilicon, ferroferric oxide, polymeric microspheres, micro and mesoporous materials, etc…”

“…[3] Also, supports provide a suitable surface for doing organic reactions. Various supports have been reported for immobilization of metalloporphyrins like chitosan, [4] organosilicon, [5] ferroferric oxide, [6] polymeric microspheres, [7] micro and mesoporous materials, [8] etc. [9] Graphene, which consists of a one-atom-thick planar sheet comprising an sp 2 -bonded carbon structure with exceptionally high crystal and electronic quality, is a novel material that has emerged as a rapidly rising star in the field of material science.…”

Photo‐inactivation of Bacillus endospores: inter‐specific variability of inactivation efficiency

“…In addition, for clinical applications they have the advantage of being water soluble to a certain degree, being cleared within reasonable time intervals thus minimizing photosensitive reactions; they also absorb light in wavelengths that penetrate living tissues (2, 44–46). Porphyrins immobilized in different types of materials such as metals or polymers have been successfully tested for various disinfection approaches (47–51). Meso ‐substituted cationic porphyrins are reportedly equally or even more effective than other photosensitizers, such as toluidine blue O, methylene blue, crystal violet or thionin, for inactivation of pathogenic microorganisms (1, 22).…”