Catalytic and synthesis of new compound based on geranium oil

M’hammed, Elmeliani; Djafri, Fatiha; Djafri, Ayada; Said, Bodfer; Mohamed, Kharsi

doi:10.21608/ejchem.2021.65454.3402

Cited by 1 publication

(2 citation statements)

References 15 publications

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“…After some modifications, the agar diffusion approach is used for the antifungal analysis of pyrazole-and imidazole-based derivatives. In short, after isolation and preparation of the Fusarium fungus, the sterilized solution of the six compounds tested (1)(2)(3)(4)(5)(6) in dimethyl sulfoxide (DMSO) is mixed with the potato dextrose agar (PDA) medium as an emulsifier at different concentrations using the method mentioned in the literature [16]. These compounds were synthesized by Takfaoui et al using direct diarylation of pyrazoles and imidazoles with aryl halides, using palladium as the catalyst, DMAc as the solvent, and CsOAc as the base [64,65].…”

Section: Pyrazole-and Imidazole-based Derivativesmentioning

confidence: 99%

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An Insight into All Tested Small Molecules against Fusarium oxysporum f. sp. Albedinis: A Comparative Review

et al. 2022

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Bayoud disease affects date palms in North Africa and the Middle East, and many researchers have used various methods to fight it. One of those methods is the chemical use of synthetic compounds, which raises questions centred around the compounds and common features used to prepare targeted molecules. In this review, 100 compounds of tested small molecules, collected from 2002 to 2022 in Web of Sciences, were divided into ten different classes against the main cause of Bayoud disease pathogen Fusarium oxysporum f. sp. albedinis (F.o.a.) with structure–activity relationship (SAR) interpretations for pharmacophore site predictions as (δ−···δ−), where 12 compounds are the most efficient (one compound from each group). The compounds, i.e., (Z)-1-(1.5-Dimethyl-1H-pyrazole-3-yl)-3-hydroxy but-2-en-1-one 7, (Z)-3-(phenyl)-1-(1,5-dimethyl-1H-pyrazole-3-yl)-3-hydroxyprop-2-en-1-one 23, (Z)-1-(1,5-Dimethyl-1H-pyrazole-3-yl)-3-hydroxy-3-(pyridine-2-yl)prop-2-en-1-one 29, and 2,3-bis-[(2-hydroxy-2-phenyl)ethenyl]-6-nitro-quinoxaline 61, have antifungal pharmacophore sites (δ−···δ−) in common in N1---O4, whereas other compounds have only one δ− pharmacophore site pushed by the donor effect of the substituents on the phenyl rings. This specificity interferes in the biological activity against F.o.a. Further understanding of mechanistic drug–target interactions on this subject is currently underway.

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Section: Pyrazole-and Imidazole-based Derivativesmentioning

confidence: 99%

“…Bayoud disease [1][2][3][4][5], caused by the telluric fungus pathogen Fusarium oxysporum f. sp. albedinis (F.o.a) [6][7][8][9], represents the leading dangerous agent of date palms cultivation, having killed more than 15 million Moroccan and Algerian date palm trees.…”

Section: Introductionmentioning

confidence: 99%