“…[3] Strategies which have been developed recently include the use of dynamic kinetic resolution [4] and dy-namic thermodynamic resolution, [5] resolutions based on sulfoxide chemistry, [5,6] and atropselective transition-metal-catalysed coupling. [7] Enzymatic desymmetrisation is an appealing method for asymmetric synthesis, [8,9] but it is noteworthy that only three examples of enzymatic desymmetrisation applied to atropisomers have been reported, [9][10][11] and only two of these involve the most common class of atropisomers, the biaryls. [9] We now report that simple symmetrical biaryls may be desymmetrised by a rapid enantioselective oxidation catalysed by a variant of galactose oxidase (GOase M 3-5 ) developed in our group previously, [12] or alternatively (and complementarily) by enantioselective reduction by using a panel of ketoreductases (KREDs).…”