Catalytic effect of copper(II) chloride on the radioiodination of L-p-iodophenylalanine

Facile calculation of specific rate constants and activation energies of 18F-fluorination reaction using combined processes of coat-capture–elution and microfluidics

“…1]. 24,25 In this model, labeling efficiency graphs could be converted to line graphs of reaction time versus log(1ÀF) [Eq. 2] (Fig.…”

Radiohalogens for imaging and therapy

“…Halogen exchange reactions are the most common nucleophilic method for the introduction of radioiodine nuclides into organic molecules. Frequently, either ammonium sulfate or copper(II) salts 20 are used to catalyze the iodide for iodine exchange, as is the case for the synthesis of meta-[ 131 I]iodobenzylguanidine ([ 131 I]MIBG) shown in Scheme 6. 21 MIBG is used for the diagnosis and therapy of certain brain tumors depending on the iodine isotope used.…”

Synthesis of Halogenated α‐Amino Acids

“…There are now many chiral glycinate equivalents and chiral catalysts available which have the potential to enable modification of this approach for the synthesis of enantioenriched products. Radiolabeled iodophenylalanine has been used for pancreatic imaging studies and, in particular, to detect tumors [62]. Many methods are known for introducing iodine CO b-Hydroxyphenylalanine and b-hydroxytyrosine are components of several biologically active compounds including vancomycin which contains both (2S,3R)-and (2R,3R)-b-hydroxytyrosine residues whilst the structure of lysobactin includes a (2S,3R)-b-hydroxyphenylalanine ( [65,66] and references cited therein).…”