Catalytic upgrading of butyric acid towards fine chemicals and biofuels

Sjöblom, Magnus; Μάτσακας, Λεωνίδας; Christakopoulos, Paul

doi:10.1093/femsle/fnw064

Cited by 25 publications

(15 citation statements)

References 44 publications

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“…Butyl esters are valuable fuel sources that can be processed with other petroleum-based products. In addition, butyl esters show interesting properties like a high boiling point, low viscosity, and low temperature behaviors for food and cosmetic industries [38,39]. HaSGNH1 could be suitable for butyl esters production because it prefers short-chain length substrates, and butyl esters have been successfully synthesized by several other lipases [40,41].…”

Section: Synthesis Of Butyl and Oleic Estersmentioning

confidence: 99%

Biodiesel and flavor compound production using a novel promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from the psychrophilic bacterium Halocynthiibacter arcticus

Yoo

Jeon

et al. 2020

Biotechnol Biofuels

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Background: Biodiesel and flavor compound production using enzymatic transesterification by microbial lipases provides mild reaction conditions and low energy cost compared to the chemical process. SGNH-type lipases are very effective catalysts for enzymatic transesterification due to their high reaction rate, great stability, relatively small size for convenient genetic manipulations, and ease of immobilization. Hence, it is highly important to identify novel SGNH-type lipases with high catalytic efficiencies and good stabilities. Results: A promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from Halocynthiibacter arcticus was catalytically characterized and functionally explored. HaSGNH1 displayed broad substrate specificity that included tert-butyl acetate, glucose pentaacetate, and p-nitrophenyl esters with excellent stability and high efficiency. Important amino acids (N83, M86, R87, F131, and I173F) around the substrate-binding pocket were shown to be responsible for catalytic activity, substrate specificity, and reaction kinetics. Moreover, immobilized HaSGNH1 was used to produce high yields of butyl and oleic esters. Conclusions: This work provides a molecular understanding of substrate specificities, catalytic regulation, immobilization, and industrial applications of a promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from H. arcticus. This is the first analysis on biodiesel and flavor synthesis using a cold-adapted halophilic SGNH-type lipase from a Halocynthiibacter species.

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Section: Synthesis Of Butyl and Oleic Estersmentioning

confidence: 99%

Biodiesel and flavor compound production using a novel promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from the psychrophilic bacterium Halocynthiibacter arcticus

Yoo

Jeon

et al. 2020

Biotechnol Biofuels

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“…Salts of butyric acid are known as butyrates. Butyric acid is a chemical, commonly used as a precursor to produces other substances, like biofuel [92,93], cellulose acetate [94,95], and methyl butyrates [96], the two last coatings, and flavors compounds, respectively. Chemical synthesis is still the primary way of production of butyric acid due to the availability of raw material [92].…”

Section: Butyric Acidmentioning

confidence: 99%

Bioconversion of Lactose from Cheese Whey to Organic Acids

Pais-Chanfrau¹,

Núñez-Pérez²,

Espín-Valladares³

et al. 2020

Lactose and Lactose Derivatives

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Organic acids constitute a group of organic compounds that find multiple applications in the food, cosmetic, pharmaceutical, and chemical industries. For this reason, the market for these products is continuously growing. Traditionally, most organic acids have been produced by chemical synthesis from oil derivatives. However, the irreversible depletion of oil has led us to pay attention to other primary sources as possible raw materials to produce organic acids. The microbial production of organic acids from lactose could be a valid, economical, and sustainable alternative to guarantee the sustained demand for organic acids. Considering that lactose is a by-product of the dairy industry, this review describes different procedures to obtain organic acids from lactose by using microbial bioprocesses.

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“…However, the acids can be converted in many ways to alcohols or other products of interest as outlined by Sjöblom et al . ( 2016 ). The message here is to keep the eyes open to find creative solutions to pending problems based on nature's capabilities.…”

Section: The Process—from Substrate Via Microbe To Purificationmentioning

confidence: 99%

Industrial production of acetone and butanol by fermentation—100 years later

Sauer

2016

FEMS Microbiology Letters

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Microbial production of acetone and butanol was one of the first large-scale industrial fermentation processes of global importance. During the first part of the 20th century, it was indeed the second largest fermentation process, superseded in importance only by the ethanol fermentation. After a rapid decline after the 1950s, acetone-butanol-ethanol (ABE) fermentation has recently gained renewed interest in the context of biorefinery approaches for the production of fuels and chemicals from renewable resources. The availability of new methods and knowledge opens many new doors for industrial microbiology, and a comprehensive view on this process is worthwhile due to the new interest. This thematic issue of FEMS Microbiology Letters, dedicated to the 100th anniversary of the first industrial exploitation of Chaim Weizmann's ABE fermentation process, covers the main aspects of old and new developments, thereby outlining a model development in biotechnology. All major aspects of industrial microbiology are exemplified by this single process. This includes new technologies, such as the latest developments in metabolic engineering, the exploitation of biodiversity and discoveries of new regulatory systems such as for microbial stress tolerance, as well as technological aspects, such as bio- and down-stream processing.

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Catalytic upgrading of butyric acid towards fine chemicals and biofuels

Cited by 25 publications

References 44 publications

Biodiesel and flavor compound production using a novel promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from the psychrophilic bacterium Halocynthiibacter arcticus

Biodiesel and flavor compound production using a novel promiscuous cold-adapted SGNH-type lipase (HaSGNH1) from the psychrophilic bacterium Halocynthiibacter arcticus

Bioconversion of Lactose from Cheese Whey to Organic Acids

Industrial production of acetone and butanol by fermentation—100 years later

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