2020
DOI: 10.26434/chemrxiv.12003444.v1
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Catalytic α-Hydroarylation of Acrylates and Acrylamides via an Interrupted Hydro-Dehalogenation Reaction

Abstract: The palladium-catalyzed, α-selective hydroarylation of acrylates and acrylamides is reported. Under optimized conditions, this method is highly tolerant of a wide range of substrates including those with base sensitive functional groups and/or multiple enolizable carbonyl groups. A detailed mechanistic study was undertaken, and the high selectivity of this transformation was shown to be enabled by the formation of an [Pd<sup>II</sup>(Ar)(H)] intermediate, which performs selective hydride insertion … Show more

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