Catalyzed Crystallization of Glass-Forming Melts

Gutzow, I.; Schmelzer, Jürn W. P.

doi:10.1007/978-3-642-34633-0_7

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…For supersaturating formulations, particularly ASDs, additives such as polymers and surfactants are traditionally used to increase the dissolution rate and inhibit crystallization. Many studies have focused on the role of polymers in mitigating crystallization by delaying the onset of nucleation − or reducing crystal growth through adsorption of the polymer on the crystal surface. − In contrast, surfactants have been found to either delay or promote crystallization, depending on the specific surfactant and drug combination. ,, …”

Section: Introductionmentioning

confidence: 99%

Crystallization Kinetics in Fasted-State Simulated and Aspirated Human Intestinal Fluids

Elkhabaz

Moseson

Sarkar

et al. 2021

Crystal Growth & Design

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To enhance the bioavailability of poorly soluble therapeutics, enabling formulations that generate supersaturation are currently of great interest. There is limited knowledge of how the gastrointestinal environment can influence the complex phase behavior of these systems, in particular, crystallization. Simulated media are generally used to mimic physiologically relevant fluids, although their predictability remains unknown for crystallizing systems since they are simplified models of the gastrointestinal fluids. The purpose of this study was to evaluate and compare how different simulated media, as well as aspirated intestinal fluid, impact the phase behavior of supersaturated solutions of two poorly soluble compounds, atazanavir and posaconazole, in fasted-state conditions. The onset of nucleation and progression of crystallization were found to be highly medium dependent. In the aspirated fluid, the crystallization kinetics for both compounds was significantly reduced compared to commercial simulated media. The use of simple buffers or current simulated fluids as surrogates for intestinal fluids appears to require further verification when attempting to predict crystallization kinetics of supersaturated solutions, based on the observed lack of correlation between commercial media and human fluids. The findings highlight the importance of carefully considering the composition of in vitro testing media for assessing crystallization kinetics, particularly in the context of supersaturating formulations.

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Section: Introductionmentioning

confidence: 99%

Crystallization Kinetics in Fasted-State Simulated and Aspirated Human Intestinal Fluids

Elkhabaz

Moseson

Sarkar

et al. 2021

Crystal Growth & Design

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“…nonzero thickness of the interphase layer and variability of nuclei composition. Changing of nuclei composition causes inconstancy of surface tension that can be accounted in terms of generalized nucleation theory [4]. Both these factors are considered in nonclassical nucleation theory (NCNT) developed by Cahn and Hilliard (CH) [5,6].…”

Section: Introductionmentioning

confidence: 99%

Generalized non-classical nucleation model in binary alloys

L’vov

Светухин

2019

Modelling Simul. Mater. Sci. Eng.

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In this study, we have developed the generalized non-classical nucleation model in binary alloys. The model implies application of Cahn–Hilliard or (and) Cahn–Hilliard–Cook (CHC) equations to determine kinetic coefficients and boundary conditions for master equation. Also, we have extracted properties of critical nuclei, i.e. size, average composition and nucleation barrier, from direct simulation by the CHC equation.

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