Catalyzed synthesis of β-amino acids esters

Aspartic acid in a new role: Synthesis and application of a pH-responsive cyclopolymer containing residues of the amino acid

“…A mixture of dimethyl maleate 2 (60.2 g, 417 mmol), montmorillonite K10 (21 g), methanol (23 cm 3 ), and diallylamine (120 g, 1.23 mol) was stirred at 40°C for 72 h [26]. The catalyst was filtered off and washed with dichloromethane (75 cm 3 ).…”

Cinchona Alkaloid Derivative-Catalyzed Enantioselective Synthesis via a Mannich-Type Reaction and Antifungal Activity of β-Amino Esters Bearing Benzoheterocycle Moieties

“…Cephalosporins and carbapenems (Figure 1) exhibit a broad spectrum of antibacterial activity. β-Amino acid ester derivatives can be used as building blocks for the synthesis of these types of antibiotics, making them useful in drug synthesis and other fields [10,11,12,13].…”

Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

“…β-Amino ester derivatives are key intermediate in the synthesis of β-lactam antibiotics, which are important components of many natural products and therapeutic agents [12,13,14]. Therefore, the asymmetric synthesis of β-amino ester derivatives has become a field of increasing interest in organic synthetic chemistry over the past few years [15,16,17,18,19,20].…”

“…As an extension study of our group’s research [19,21], we have now synthesized a series of novel β-amino ester derivatives containing benzofuran and benzothiazole units. The structures of these newly synthesized compounds were confirmed by 1 H-NMR, 13 C-NMR, IR spectra, and MS (HREI) analysis.…”