Catechol derivatives-coated Fe3O4 and γ-Fe2O3 nanoparticles as potential MRI contrast agents

Basti, H.; Tahar, Lotfi Ben; Smiri, Leila Samia; Herbst, Frédéric; Vaulay, M.-J.; Chau, François; Ammar, Souad; Benderbous, Soraya

doi:10.1016/j.jcis.2009.09.043

Cited by 161 publications

(92 citation statements)

References 36 publications

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“…16 Hot water was used to wash out the adsorbed organic residues on the NP surfaces and oxidize them to the maghemite form. The structure, size and shape of the particles produced were investigated by X-ray diffraction (PANalytical X'PertPro; PANalytical, Almelo, the Netherlands) and transmission electron microscopy (JEOL 100-CX II, 100 kV; JEOL, Tokyo, Japan).…”

Section: Iron Oxide Np Synthesis Characterization and Labelingmentioning

confidence: 99%

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Evaluation of iron oxide nanoparticle biocompatibility

Hanini¹,

Schmitt²,

Kacem³

et al. 2011

IJN

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Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe 2 O 3 nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe 2 O 3 can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe 2 O 3 nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe 2 O 3 could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.

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Section: Iron Oxide Np Synthesis Characterization and Labelingmentioning

confidence: 99%

“…These results are in agreement with the average crystal size inferred from X-ray diffraction line broadening using the Scherrer formula. 16,18 There is no evidence of physical defects such as dislocation and stacking, or of amorphous regions at the surface, suggesting high crystalline quality in single particles.…”

Section: Iron Oxide Np Characterizationmentioning

confidence: 99%

Evaluation of iron oxide nanoparticle biocompatibility

Hanini¹,

Schmitt²,

Kacem³

et al. 2011

IJN

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“…The reactive amino groups of DPA can then act as coupling links for further association with modifying or cell targeting agents. 28 In this report, an ionic DPA-HA associate was first prepared and added to γ-Fe 2 O 3 nanoparticles, with DPA being attached to iron oxide via hydroxyl groups, 29 while amino groups associated HA (Figure 3). According to TEM, the size of the DPA-HA-γ-Fe 2 O 3 particles was between 7.6-9.5 nm ( Figure 1B and C), ie, almost the same as that of neat particles.…”

Section: Nnn′n′-tetramethyl-o-(n-succinimidyl)uroniummentioning

confidence: 99%

The use of dopamine-hyaluronate associate-coated maghemite nanoparticles to label cells

Horák¹,

Babic²,

Jendelova³

et al. 2012

IJN

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Sodium hyaluronate (HA) was associated with dopamine (DPA) and introduced as a coating for maghemite (γ-Fe 2 O 3 ) nanoparticles obtained by the coprecipitation of iron(II) and iron(III) chlorides and oxidation with sodium hypochlorite. The effects of the DPA anchorage of HA on the γ-Fe 2 O 3 surface on the physicochemical properties of the resulting colloids were investigated. Nanoparticles coated at three different DPA-HA/γ-Fe 2 O 3 and DPA/HA ratios were chosen for experiments with rat bone marrow mesenchymal stem cells and human chondrocytes. The nanoparticles were internalized into rat bone marrow mesenchymal stem cells via endocytosis as confirmed by Prussian Blue staining. The efficiency of mesenchymal stem cell labeling was analyzed. From among the investigated samples, efficient cell labeling was achieved by using DPA-HA-γ-Fe 2 O 3 nanoparticles with DPA-HA/γ-Fe 2 O 3 = 0.45 (weight/ weight) and DPA/HA = 0.038 (weight/weight) ratios. The particles were used as a contrast agent in magnetic resonance imaging for the labeling and visualization of cells.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) are forerunners in this development [2] due to their fascinating physico-chemical [3,4] (i.e. superparamagnetic) properties, which make them exceptional candidates for a broad variety of clinical applications, ranging from basic contrast agents [5][6][7][8] or thermoregulators [9] to sophisticated drug delivery vectors [10][11][12][13]. Nonetheless, the therapeutic window with respect to the efficiency of these materials, in other words the size range in which these properties can be exploited, is relatively small: nanoparticles larger than approximately 20 nm [14] lose their superparamagnetic properties, whereas ultrasmall single nanoparticles (i.e.…”

Section: Introductionmentioning

confidence: 99%

Catechol-derivatized poly(vinyl alcohol) as a coating molecule for magnetic nanoclusters

Burnand

Monnier

Redjem

et al. 2015

Journal of Magnetism and Magnetic Materials

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Surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs) remains indispensable in promoting colloidal stability and biocompatibility. We propose a well-defined and characterized synthesis of a new catechol-functionalized RAFT (reversible addition-fragmentation chain transfer) poly (vinyl alcohol) polymer, which can be anchored onto hydrophobic SPIONs via a one-pot emulsion ligand exchange process. Both single and clustered nanoparticles are obtained and can be separated from each other. As clustered SPIONs are receiving increasing attention, this new macroligand might be of considerable interest for both basic and applied sciences.

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Catechol derivatives-coated Fe3O4 and γ-Fe2O3 nanoparticles as potential MRI contrast agents

Cited by 161 publications

References 36 publications

Evaluation of iron oxide nanoparticle biocompatibility

Evaluation of iron oxide nanoparticle biocompatibility

The use of dopamine-hyaluronate associate-coated maghemite nanoparticles to label cells

Catechol-derivatized poly(vinyl alcohol) as a coating molecule for magnetic nanoclusters

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