Catechol modification of non-woven chitosan gauze for enhanced hemostatic efficacy

He, Huaying; Sun, Changzheng; Weng, Yunxiang; Huang, Hongjian; Ni, Peng; Fang, Yan; Xu, Renfeng; Wang, Zhengchao; Liu, Haiqing

doi:10.1016/j.carbpol.2022.119319

Cited by 34 publications

(18 citation statements)

References 36 publications

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“…New research in this area seeks to devise composite materials to improve the hemostatic properties or exploit said properties to hasten regeneration in damaged tissue [ 101 ]. For example, He et al prepared composite gauzes composed of chitosan and alginate and similar gauzes surface-modified with a catechol [ 104 ]. The former failed to match pristine chitosan gauze as a hemostat [ 104 ].…”

Section: Applicationsmentioning

confidence: 99%

“…For example, He et al prepared composite gauzes composed of chitosan and alginate and similar gauzes surface-modified with a catechol [ 104 ]. The former failed to match pristine chitosan gauze as a hemostat [ 104 ]. The gauze containing catechol, by comparison, reduced blood loss to 17% that of the pristine chitosan when compared in femoral artery and liver wounds in a rat model [ 104 ].…”

Section: Applicationsmentioning

confidence: 99%

“…The former failed to match pristine chitosan gauze as a hemostat [ 104 ]. The gauze containing catechol, by comparison, reduced blood loss to 17% that of the pristine chitosan when compared in femoral artery and liver wounds in a rat model [ 104 ]. This composite dressing also reduced the secondary bleeding induced by removal of the dressing [ 104 ].…”

Section: Applicationsmentioning

confidence: 99%

“…The gauze containing catechol, by comparison, reduced blood loss to 17% that of the pristine chitosan when compared in femoral artery and liver wounds in a rat model [ 104 ]. This composite dressing also reduced the secondary bleeding induced by removal of the dressing [ 104 ]. Pang et al exploited the hemostatic and antimicrobial effects of chitin and chitosan through the synthesis of chitosan/dextran hydrogels reinforced with chitin nanowhiskers for use as a tissue adhesive [ 105 ].…”

Section: Applicationsmentioning

confidence: 99%

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Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications

2022

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Crustacean shells are a sustainable source of chitin. Extracting chitin from crustacean shells is ongoing research, much of which is devoted to devising a sustainable process that yields high-quality chitin with minimal waste. Chemical and biological methods have been used extensively for this purpose; more recently, methods based on ionic liquids and deep eutectic solvents have been explored. Extracted chitin can be converted into chitosan or nanochitin. Once chitin is obtained and modified into the desired form, it can be used in a wide array of applications, including as a filler material, in adsorbents, and as a component in biomaterials, among others. Describing the extraction of chitin, synthesis of chitosan and nanochitin, and applications of these materials is the aim of this review. The first section of this review summarizes and compares common chitin extraction methods, highlighting the benefits and shortcomings of each, followed by descriptions of methods to convert chitin into chitosan and nanochitin. The second section of this review discusses some of the wide range of applications of chitin and its derivatives.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

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Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications

2022

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“…Gelatin is also non-immunogenic and hemocompatible, and contains the similar components and exhibits the same biological properties as collagen. 13,14 Wu developed a novel 3D nanofibrous sponge from gelatin that showed great potential as an absorbable hemostatic agent for rapid hemostasis. 15 Compared with traditional hemostatic wound dressings, such as skimmed gauze and hemostatic sponges, the gelatin nanofiber hemostatic membrane rapidly absorbed blood and enriched platelets in the wounds.…”

Section: Introductionmentioning

confidence: 99%

Gelatin/calcium chloride electrospun nanofibers for rapid hemostasis

Gao

et al. 2023

Biomater. Sci.

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Marine‐Derived Nanozyme‐Crosslinked Self‐Adaptive Hydrogels for Programmed Regulating the Regeneration Process

Wang,

Wen,

et al. 2024

Adv Funct Materials

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Self‐adaptive hydrogels that can specifically respond to pathological cues and match the highly ordered tissue regeneration process are significantly on‐demand for effective wound management. Herein, multifunctional marine‐derived gold clusterzyme (AuNCs)‐based self‐adaptive hydrogels with microenvironment triggered release behavior are elaborately fabricated for on‐demand antioxidant, anti‐inflammatory and immunoregulation. The marine mussel‐derived catechol ligands (L‐3,4‐dihydroxyphenylalanine) endow AuNCs with enhanced superoxide dismutase‐mimic activity due to their high affinity to superoxide anion free radical (O2−•) and unique electron transfer mechanism, leading to 100% inhibition of O2−•. Upon uniformly crosslinking with phenylboronic acid‐modified marine‐derived sodium alginate (PBA‐Sa), the obtained AuNCs@PBA‐Sa hydrogels exhibit outstanding self‐healing property, tunable degradation and good removability. Meanwhile, AuNCs can greatly enhance the mechanical property and confer the hydrogel with favorable tissue adhesion for rapid hemostasis. Furthermore, injectable AuNCs@PBA‐Sa hydrogels can not only adapt their shape to the irregular wound, but also smartly adapt their microstructure to the physiological microenvironment of diabetic wound, leading to the responsive release of AuNCs upon the break of boronate ester bonds. The released gold clusterzymes can actively induce the generation of M2‐macrophage, demonstrating an outstanding anti‐inflammatory and pro‐regeneration effect. Therefore, the present multifunctional clusterzyme‐based self‐adaptive hydrogels hold great potential for remolding the dynamic tissue regeneration microenvironment and smart wound management.

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Catechol modification of non-woven chitosan gauze for enhanced hemostatic efficacy

Cited by 34 publications

References 36 publications

Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications

Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications

Gelatin/calcium chloride electrospun nanofibers for rapid hemostasis

Marine‐Derived Nanozyme‐Crosslinked Self‐Adaptive Hydrogels for Programmed Regulating the Regeneration Process

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