Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat

Iqbal, Khursheed; Dhakal, Pramod; Pierce, Stephen; Soares, Michael J.

doi:10.1007/s43032-020-00348-7

Cited by 12 publications

(13 citation statements)

References 50 publications

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“…Targeted mutations were generated using clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) genome editing ( Iqbal et al. 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Targeted mutations were generated using clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) genome editing (Iqbal et al 2021). For Ahr gene editing, a single guide RNA (gRNA) was designed, synthesized, and validated by the Genome Engineering Center at Washington University (St. Louis, MO).…”

Section: Generation Of Ahr and Cyp1a1 Mutant Ratsmentioning

confidence: 99%

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Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure

Iqbal

Pierce

Kozai

et al. 2021

Environ Health Perspect

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“…Targeted mutations were generated using clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) genome editing ( Iqbal et al. 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Generation Of Ahr and Cyp1a1 Mutant Ratsmentioning

confidence: 99%

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure

Iqbal

Pierce

Kozai

et al. 2021

Environ Health Perspect

Self Cite

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“…75 However, COMT knockout in rats was associated with no preeclampsia-like phenotype. 76 Whether this discrepancy is related to differences in placentation between mice and rats has not been resolved.…”

Section: Disease Models Of Cardiovascular Complications Of Pregnancymentioning

confidence: 99%

Animal Models of Cardiovascular Complications of Pregnancy

Arany

Hilfiker‐Kleiner

Karumanchi

2022

Circulation Research

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Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.

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“…As an interface to the fetal organs, the placenta is particularly interesting to understand how fetal organs might be touched by the molecule. Recently, the mechanism of action of this molecule in the placenta has been elegantly analyzed mechanistically in a rat model comparing wild type and Ahr-/- animals [ 130 ]. TCDD exposure revealed placental adaptation at low to medium doses, up to a certain level of contamination, leading eventually to pregnancy termination.…”

Section: Mechanisms Of Oxidative Stress Induction By Environmental Pollutantsmentioning

confidence: 99%

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

2022

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Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.

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Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat

Cited by 12 publications

References 50 publications

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure

Animal Models of Cardiovascular Complications of Pregnancy

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

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