2020
DOI: 10.4274/jcrpe.galenos.2019.2019.0045
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Catecholamine-induced Myocarditis in a Child with Pheochromocytoma

Abstract: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. The clinical presentation of pediatric PPGLs is highly variable. In cases with pheochromocytoma (PCC), excess catecholamine may stimulate myocytes and cause structural changes, leading to life-threatening complications ranging from stress cardiomyopathy (CM) to dilated CM. Herein, we report the case of catecholamineinduced myocarditis in a child with asymptomatic PCC. A 12-year-and-2-month-old male patient with a known diagnosis of ty… Show more

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Cited by 3 publications
(4 citation statements)
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“…In most patients, multiple cardiac manifestations are found, such as systemic arterial hypertension, a prolonged QT interval, dilated or hypertrophic cardiomyopathy, arrhythmias and more rarely myocarditis [ 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In most patients, multiple cardiac manifestations are found, such as systemic arterial hypertension, a prolonged QT interval, dilated or hypertrophic cardiomyopathy, arrhythmias and more rarely myocarditis [ 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is the cardinal but not constant sign and is particularly suggestive when associated with the clinical triad consisting of headache, sweating and palpitations [ 12 ]. In children with systemic arterial hypertension, the prevalence of pheochromocytoma is 1.7% [ 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…Myocarditis, an inflammatory condition of the heart muscle, can result from a variety of causes, including viral infections, autoimmune processes, and toxic exposures [ 1 ]. Emerging evidence suggests that prolonged exposure to high levels of catecholamines in patients with uncontrolled phaeochromocytoma can lead to direct myocardial injury and inflammation, triggering myocarditis [ 2 ]. Takotsubo cardiomyopathy, also known as “broken heart syndrome” or stress cardiomyopathy, is a condition where the heart muscle becomes temporarily weakened or stunned, typically in response to severe emotional or physical stress.…”
Section: Introductionmentioning
confidence: 99%
“…Of note, viral entry-induced angiotensin-converting enzyme 2 downregulation worsens HF via elevated level of angiotensin II and activation of the renin-angiotensin system, which was especially observed in those accompanied with hypercytokinemia. 4 Catecholamine-storm, a status of hypernorepinephrinemia resulting from excessive release of catecholamines in these circumstances may cause hypersympathetic activity including tachycardia and hypertension, consequently leading to myocardial damage, 5 acute fulminant HF, 6 and death. 7,8 Without adequate therapy, most of these involved patients would suddenly die within 4-6 h after the clinical presentation of hypernorepinephrinemia in EV-71-complicated myocarditis.…”
Section: Introductionmentioning
confidence: 99%